J
J K Browne
Researcher at Amgen
Publications - 9
Citations - 2340
J K Browne is an academic researcher from Amgen. The author has contributed to research in topics: Erythropoietin & Gene. The author has an hindex of 8, co-authored 9 publications receiving 2309 citations.
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Journal ArticleDOI
Cloning and expression of the human erythropoietin gene.
Fu-Kuen Lin,Sidney Vaughn Suggs,C H Lin,J K Browne,Richard W. Smalling,Joan C. Egrie,Kenneth Chen,G. M. Fox,F Martin,Z Stabinsky +9 more
TL;DR: The human erythropoietin gene has been isolated from a genomic phage library by using mixed 20-mer and 17-mer oligonucleotide probes and encodes a 27-amino acid signal peptide and a 166-AMino acid mature protein with a calculated Mr of 18,399.
Journal ArticleDOI
Pharmacokinetics of Novel Erythropoiesis Stimulating Protein Compared with Epoetin Alfa in Dialysis Patients
Iain C. Macdougall,Stephen J. Gray,Orlaith Elston,Cormac P. Breen,Barbara Jenkins,J K Browne,Joan C. Egrie +6 more
TL;DR: The longer half-life of NESP is likely to confer a clinical advantage over Epoetin by allowing less frequent dosing in patients treated for anemia.
Journal ArticleDOI
Characterization and biological effects of recombinant human erythropoietin.
Joan C. Egrie,T.W. Strickland,J. Lane,Ken Aoki,A.M. Cohen,R. Smalling,G. Trail,Fu-Kuen Lin,J K Browne,Dawn Hines +9 more
TL;DR: The purified human recombinant erythropoietin (rHuEPO) is biologically active and equivalent to the natural hormone by all criteria examined.
Journal ArticleDOI
Control of rHuEPO biological activity: The role of carbohydrate
Steve Elliott,Joan C. Egrie,J K Browne,Tony Lorenzini,Leigh Busse,Norma Rogers,Ponting Ian L O +6 more
TL;DR: In this article, the in vivo response of recombinant human erythropoietin (rHuEPO) was correlated with the number of N-linked carbohydrates, which was a more significant determinant for in vivo activity than position.