https://www.cell.com/trends/molecular-medicine/pdf/S1471-4914(10)00114-0.pdf

Nanosensors and nanomaterials for monitoring glucose in diabetes

The electrochemical reduction of pyrimidine and certain derivatives was investigated over the normal pH range by polarography, coulometry, and macroscale electrolysis. The reduction products were examined chemically, polarographically, and spectrophotometrically. Pyrimidine is first reduced at the 3,4 position in a le process to a free radical, which may dimerize or be reduced (le process) to 3,4-dihydropyrimidine; the latter can be further reduced (2e process) to tetrahydropyrimidine. The 2-amino- and 2-amino-4- methylpyrimidines are reduced in two le steps, first to a free radical and then to the 3,4-dihydro derivative. 4-Amino-2,6-dimethylpyrimidine gives a single 4e wave, which likeIy involves 2e reduction to the 3,4-dihydro compound followed by deamination to 2,6-dimethylpyrimi dine, which is reduced (2e prccess) to 2,6- dimethyl-3,4dihydropyrimidine. Cytosine (4-amino-2-hydroxypyrimidine) undergoes a 3e reduction, which involves 2e reduction of the 3,4 N = C bond, deamination to form 2-hydroxyPyrimidine and le reduction of the latter to a free radical which dimerizes. 2-Hydroxypyrimidine itself shows only le reduction. The dihydro and tetrahydro products are unstable in aqueous solution; pseudo first-order rate of disappearance is shown by the two compounds examined. In general, 4-amino- pyrimidines having the 3,4 position hydrogenated deaminate readily to generate the reducible 3,4 N = C bond. (auth)

ELECTROCHEMICAL REDUCTION OF PYRIMIDINE, CYTOSINE AND RELATED COMPOUNDS: POLAROGRAPHY AND MACROSCALE ELECTROLYSIS. Report No. 63

Revue bibliographique de 1983 a 1985 classee suivant: livres, transfert de masse, detecteurs, cinetique, effets de surface, electrodes modifiees chimiquement, voltammetrie analytique, caracterisation des systemes redox, bioelectrochimie, spectroelectrochimie, appareillage

Dynamic Electrochemistry: Methodology and Application

A peroxidase model electrode was devised for reagentless sensing of hydrogen peroxide (H2O2). A small model molecule, which mimics the vicinity of the reaction center of a redox enzyme, can communicate electrochemically with an electrode. Heme nonapeptide (MW congruent to 1600) having peroxidase activity was adopted as a peroxidase model compound and was covalently immobilized on a tin oxide (SnO2) electrode as a roughly monomolecular layer. The modified electrode thus obtained responded to H2O2 at concentrations down to 10(-6) M without electron mediator or promoter, at a mild potential of +150 or +300 mV vs Ag/AgCl. In a batch system, the response reached a steady state in a few seconds. Measurements were possible also in a flow system with an assay time of 0.5-1.0 min/sample. The steady-state response of the electrode was kinetically analyzed.

Peroxidase model electrodes: heme peptide modified electrodes as reagentless sensors for hydrogen peroxide.

Derivatised carbon powder electrodes: reagentless pH sensors.

Differential pulse polarography for a dimerization process

An electrochemical study of the dimerization of mesityl oxide

Diagnosis of irreversible electron transfers and reversible CEC, CE, and EC processes from differential pulse polarographic criteria

Electrochemical reduction of 7-aminodesacetoxy[5-thio-(1-N-methyltetrazoyl)]cephalosporanic acid and its determination by differential-pulse polarography

J.L. Avila

Papers

Differential pulse polarography for a dimerization process

An electrochemical study of the dimerization of mesityl oxide

Diagnosis of irreversible electron transfers and reversible CEC, CE, and EC processes from differential pulse polarographic criteria

Electrochemical reduction of 7-aminodesacetoxy[5-thio-(1-N-methyltetrazoyl)]cephalosporanic acid and its determination by differential-pulse polarography

Catalytic electrodeposition of silver on glassy carbon electrodes modified with films of cobalt phthalocyanine