The hERG channel is an important antitarget in safety pharmacology. Several drugs have been withdrawn from the market or received severe usage restrictions because of hERG-related cardiotoxicity. In a screening of medicinal plants for hERG channel inhibition using a two-microelectrode voltage clamp assay with Xenopus laevis oocytes, a dichloromethane extract of the roots of Gnidia polycephala reduced the peak tail hERG current by 58.8 ± 13.4% (n = 3) at a concentration of 100 μg/mL. By means of HPLC-based activity profiling daphnane-type diterpenoid orthoesters (DDOs) 1, 4, and 5 were identified as the active compounds [55.4 ± 7.0% (n = 4), 42.5 ± 16.0% (n = 3), and 51.3 ± 9.4% (n = 4), respectively, at 100 μM]. In a detailed phytochemical profiling of the active extract, 16 compounds were isolated and characterized, including two 2-phenylpyranones (15 and 16) with an unprecedented tetrahydro-4H-5,8-epoxypyrano[2,3-d]oxepin-4-one skeleton, two new DDOs (3 and 4), two new guaiane sesquiterpenoids (11 and 1...

hERG Channel Inhibitory Daphnane Diterpenoid Orthoesters and Polycephalones A and B with Unprecedented Skeletons from Gnidia polycephala

Regiospecific Demethylation—Sulfonation of 2′,3‐Dimethoxyflavones.

Reduction of amorphous carbon clusters from the highly disordered and reduced graphene oxide NPs by acoustical shock waves — Towards the formation of highly ordered graphene

The excessive or illegal use of organophosphorus pesticides (OPs) in agriculture has led to potential residue problems, making it essential to develop an effective analytical method. As reliable and rapid analytical methods, biosensors open an avenue for OP detection. However, traditional biosensors mainly depend on bio-recognition elements, consequently limiting their practical application. To address these issues, nanozymes have been widely applied because of their low cost, excellent stability, and favorable catalytic activity. This review summarizes the related research progress of nanozyme-based biosensors for OP detection in the last six years (2018–2023). The structural classification, catalytic activity, and biosensing strategy are discussed. Emphatically, this paper introduces the practical applications of nanozyme-enabled biosensors in the direction of simple operation, low cost, and on-site detection, such as optical and electrochemical biosensors. Finally, the main challenges and future trends are prospected, which could provide theoretical references for nanozyme-based biosensors in OP detection. 

J. L. Franquet Cami

Papers

Shock Processing of Amorphous Carbon Nanodust

Regiospecific Demethylation-Sulfonation of 2',3'-Dimethoxyflavones

Regiospecific Demethylation—Sulfonation of 2′,3‐Dimethoxyflavones.