This report deals with some of the calcium phosphate materials which are currently used in preventive and restorative dentistry and other calcium phosphate materials which have potential for dental and medical applications. Such materials include those which form calcium phosphate in situ (e.g., Bioglass ceramics and calcium phosphate cements) and those originating from natural materials (such as corals and bones).The reports on the development and current status of the calcium phosphate ceramics and glass ceramics presented here were based on recent reviews and recent evaluations of clinical studies for the period 1975 to 1986 (Table 3) with humans and with animals when reports on human studies were not yet available. Methods of preparation and relevant physico-chemical properties of some of the calcium phosphate materials were based on data reported in the literature and on other studies by the author. New calcium phosphate materials, e.g., calcium phosphate cements, calcium phosphate-coated implants, c...

Calcium Phosphate Materials in Restorative Dentistry: a Review:

The review is focused on the latest achievements in the field of plasma-assisted fabrication of biocompatible CaP-based coatings for medical implants with the emphasis on the coatings composition, structure, mechanical and biological performance. The discussed properties of biocompatible CaP coatings have been recently prepared using the most frequently applied plasma-assisted techniques such as plasma spraying (PS), radio-frequency (RF) magnetron sputtering, pulsed laser deposition (PLD), and ion beam-assisted deposition (IBAD). The review shows that plasma-assisted fabrication allows us to prepare dense, homogeneous, pore-free and high adherent biocompatible coatings able to prevent the leaching of toxic ions from metal to the surrounding tissues or rough and porous coatings capable of stimulating osteogenesis of a new bone. The main advantages and limitations of the described techniques of CaP-based coatings fabrication are presented as well as the most important challenges and critical issues are highlighted.

https://portal.tpu.ru/SHARED/s/SURMENEV/nauka/Tab/2012_Review_Surmenev%20-%2016_final.pdf

A review of plasma-assisted methods for calcium phosphate-based coatings fabrication

Dental implants have 89% plus survival rates at 10-15 years, but peri-implantitis or dental implant infections may be as high as 14%. Peri-implantitis can limit clinical success and impose health and financial burdens to patients and health providers. The pathogenic species associated with periodontitis (e.g., Fusobacterium ssp, A. actinomycetemcomitans, P. gingivalis) are also associated with peri-implantitis. Incidence of peri-implantitis is highest within the first 12 months after implantation, and is higher in patients who smoke or have poor oral health as well as with calcium-phosphate-coated or surface-roughened implants. Biomaterial therapies using fibers, gels, and beads to deliver antibiotics have been used in the treatment of Peri-implantitis though clinical efficacy is not well documented. Guided tissue regeneration membranes (e.g., collagen, poly-lactic/glycolic acid, chitosan, ePTFE) loaded with antimicrobials have shown success in reosseointegrating infected implants in animal models but have not been proven in humans. Experimental approaches include the development of anti-bioadhesion coatings, coating surfaces with antimicrobial agents (e.g., vancomycin, Ag, Zn) or antimicrobial releasing coatings (e.g., calcium phosphate, polylactic acid, chitosan). Future strategies include the development of surfaces that become antibacterial in response to infection, and improvements in the permucosal seal. Research is still needed to identify strategies to prevent bacterial attachment and enhance normal cell/tissue attachment to implant surfaces.

https://www.onlinelibrary.wiley.com/doi/pdf/10.1002/jbm.b.31152

Biomaterial and antibiotic strategies for peri-implantitis: a review

This study aimed to assess the literature available on the effects, on peri-implant tissues, of degradation products released from dental implants as a consequence of therapeutic treatment for peri-implantitis and/or of wear-corrosion of titanium. A literature review of the PubMed medline database was performed up to December 31, 2016. The following search terms were used: "titanium wear and dental implant"; "titanium corrosion and dental implant"; "bio-tribocorrosion"; "peri-implantitis"; "treatment of peri-implantitis"; "titanium particles release and dental implant"; and "titanium ion release and dental implant". The keywords were applied to the database in different combinations without limits of time period or type of work. In addition, the reference lists of relevant articles were searched for further studies. Seventy-nine relevant scientific articles on the topic were retrieved. The results showed that pro-inflammatory cytokines, infiltration of inflammatory response cells and activation of the osteoclasts activity are stimulated in peri-implant tissues in the presence of metal particles and ions. Moreover, degenerative changes were reported in macrophages and neutrophils that phagocytosed titanium microparticles, and mutations occurred in human cells cultured in medium containing titanium-based nanoparticles. Debris released from the degradation of dental implants has cytotoxic and genotoxic potential for peri-implant tissues. Thus, the amount and physicochemical properties of the degradation products determine the magnitude of the detrimental effect on peri-implant tissues.

J Natiella

Papers

Biomaterials, biocompatibility, and peri-implant considerations.