J
J.P. Orme
Researcher at AstraZeneca
Publications - 2
Citations - 154
J.P. Orme is an academic researcher from AstraZeneca. The author has contributed to research in topics: Pyruvate decarboxylation & Pyruvate dehydrogenase complex. The author has an hindex of 2, co-authored 2 publications receiving 140 citations.
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Journal ArticleDOI
AZD7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) Zucker rats.
Rachel M. Mayers,R.J. Butlin,E. Kilgour,Brendan Leighton,D. Martin,J. Myatt,J.P. Orme,B.R. Holloway +7 more
TL;DR: AZD7545 (10 mg/kg) twice daily for 7 days markedly improved the 24-h glucose profile, by eliminating the postprandial elevation in blood glucose, suggesting that PDHK inhibitors may be beneficial agents for improving glucose control in the treatment of type 2 diabetes.
Journal ArticleDOI
AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2
TL;DR: The isoenzyme-selectivity profile of AZD7545 and related compounds is described and the consequences for their in vivo mode of action are discussed.