J
J P Whelan
Researcher at University of Pennsylvania
Publications - 7
Citations - 347
J P Whelan is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Beta-2 microglobulin & Major histocompatibility complex. The author has an hindex of 6, co-authored 7 publications receiving 345 citations. Previous affiliations of J P Whelan include Children's Hospital of Philadelphia.
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Journal Article
Striking paucity of HLA-A, B, C and beta 2-microglobulin on human neuroblastoma cell lines.
TL;DR: Monoclonal antibodies to beta 2-microglobulin (beta 2m), and to the native two-chain molecule, were used to assess the expression of the HLA-A, B, C molecules on human neuroblastoma-derived cell lines, and confirmed that a beta m-like chain is synthesized by the neuro Blastoma cells, but the Hla chain could not be visualized by this technique.
Journal Article
HLA Class I and β2-Microglobulin Expression in Frozen and Formaldehyde-fixed Paraffin Sections of Neuroblastoma Tumors
TL;DR: The localization of most of the positive cells near stromal tissue and blood vessels suggests that most of these cells may be of non-tumor origin, which extends previous reports of weak beta 2-m and HLA-class I levels in cells of neuronal origin.
Journal Article
Expression of mouse beta 2-microglobulin in frozen and formaldehyde-fixed central nervous tissues: comparison of tissue behind the blood-brain barrier and tissue in a barrier-free region.
TL;DR: Failure to detect beta 2-m in the area postrema suggests that passive exposure to environmental antigens, immunomodulators, or immunocompetent cells is not sufficient to induce neural class I expression, and if increased expression of beta 1-m and class I occurs in vivo, additional stimulus is required.
Journal Article
HLA-A,B,C and beta 2-microglobulin are expressed weakly by human cells of neuronal origin, but can be induced in neuroblastoma cell lines by interferon.
Journal Article
Distribution of beta 2-microglobulin in olfactory epithelium: a proliferating neuroepithelium not protected by a blood-tissue barrier.
TL;DR: Results suggest that lack of beta 2-m, and presumably class I, may be a general phenotype of neuronal cells regardless of their mitotic state or exposure to environmental antigens.