Showing papers by "J. R. Siewert published in 1987"

[Cardia cancer: attempt at a therapeutically relevant classification].

Abstract: On the basis of a prospective analysis of 107 adenocarcinomas of the gastro-esophageal junction we propose a differentiation into adenocarcinomas of Barrett's esophagus (endobrachyesophagus), "real" carcinoma of the cardia, and subcardial carcinoma of the fundus. This classification allows the determination of an adequate surgical resection. Therefore the operative risk can be kept low. Total esophagogastrectomy is reserved only for advanced "real" carcinomas of the cardia in this concept.

Perioperative chemotherapy in squamous cell carcinomas of the esophagus

Abstract: In the majority of patients with esophageal cancer local tumor infiltration and/or distant metastases are responsible for the poor prognosis. Therefore to improve life expectancy additional modalities - chemotherapy alone or in combination with simultaneous radiation - have been introduced perioperatively. In spite of a possible increase of resectability convincing data are lacking which could argue for an uncontrolled introduction of the neoadjuvant approach outside investigational studies.

Perioperative Chemotherapie bei Plattenepithelcarcinomen des Oesophagus

Abstract: Fur die Mehrzahl der Patienten mit Oesophaguscarcinomen sind lokale Tumorinfiltrationen und/oder Fernmetastasen bei der Diagnosestellung fur die ungunstige Prognose verantwortlich zu machen. Zu deren Verbesserung werden zusatzliche Therapiemodalitaten — Chemotherapie allein oder in Kombination mit simultaner Strahlentherapie — perioperativ eingesetzt. Trotz einer moglichen Steigerung der Resektionsrate fehlen bisher uberzeugende Ergebnisse, die in fruhen Tumorstadien angesichts der gesteigerten Toxizitat einen Einsatz dieser multimodalen Therapiestrategie auserhalb von kontrollierten Studien erlauben.