J
J. R. Traynor
Researcher at Loughborough University
Publications - 4
Citations - 100
J. R. Traynor is an academic researcher from Loughborough University. The author has contributed to research in topics: Binding site & Diprenorphine. The author has an hindex of 4, co-authored 4 publications receiving 99 citations.
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Journal ArticleDOI
Differential Effects of Mg2+ and Other Divalent Cations on the Binding of Tritiated Opioid Ligands
TL;DR: The results suggest that Mg2+ ions promote binding by an action at the opioid receptor, even in the absence of G protein, and that opioid antagonists may differ in their recognition of opioid receptor binding sites.
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Formation of [Leu5]enkephalin from dynorphin A(1-8) by rat central nervous tissue in vitro.
D. M. Dixon,J. R. Traynor +1 more
TL;DR: In the presence of the peptidase inhibitors bestatin, captopril, thiorphan, and leucylleucine, [3H][Leu5]enkephalin was the major metabolic product, accounting for 60% of recovered activity.
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[3H]Diprenorphine Binding to k‐Sites in Guinea‐Pig and Rat Brain: Evidence for Apparent Heterogeneity
M. S. Wood,J. R. Traynor +1 more
TL;DR: Sequential displacement of bound [3H]diprenorphine by ligands with selectivity for μ‐, 8‐ δ, and k‐opioid receptors uncovers the multiple components of binding.
Journal ArticleDOI
Characterisation of κ-opioid binding sites in rat and guinea-pig spinal cord
TL;DR: In guinea-pig cord, under conditions in which binding to μ- and δ-sites was suppressed, [3H]dynorphin A(1–9) and [3h]U-69593 labelled only 60% of the κ population, defined by the [3 H]unselective ligands.