The rapid spread of bacteria expressing multi-drug resistance propels the search for new antibacterial agents. The present study was designed to evaluate the antibacterial activities of the methanol extracts from Beilschmiedia obscura and six other Cameroonian plants against a panel of twenty nine Gram-negative bacteria including Multi-drug resistant (MDR) phenotypes. The phytochemical investigations of the extracts were carried out according to the standard methods and the liquid micro-dilution assay was used for all antibacterial assays. Phytochemical analysis showed the presence of alkaloids in all studied extracts. Other chemical classes of secondary metabolites such as anthocyanines, anthraquinones flavonoids, saponins, tannins, sterols and triterpenes were selectively detected in the extracts. The extract from the fruits of Beilschmiedia obscura, Pachypodanthium staudtii leaves and Peperomia fernandopoiana (whole plant) displayed the best spectrum of activity with MIC values ranging from 16 to 1024 μg/mL against at least 65% and above of the tested bacteria. The extract from Beilschmiedia obscura was the most active with MIC values below 100 μg/mL against ten of the tested bacteria. This extract also showed MBC values below 1024 μg/mL against 55.17% of the studied microorganisms. Phenylalanine arginine β-naphthylamide (PAβN) significantly modulated the activities of extracts from the leaves and fruits of Pachypodanthium staudtii and Beilschmiedia obscura respectively, by increasing their inhibitory activity against Klebsiella pneumoniae KP55 strain at least four fold. The overall results of the present investigation provide information for the possible use of the methanol extracts of the studied plant species, especially B. obscura to fight infectious diseases caused by Gram-negative bacteria including MDR phenotypes.

/pdf/antibacterial-activities-of-beilschmiedia-obscura-and-six-2wnlivaheg.pdf

Antibacterial activities of Beilschmiedia obscura and six other Cameroonian medicinal plants against multi-drug resistant Gram-negative phenotypes

Antileishmanial activity of furoquinolines and coumarins from Helietta apiculata.

Biochemical systematics and ecology of the toddalioideae in the central part of the West African forest zone

Manganese(III) acetate mediated radical reactions leading to araliopsine and related quinoline alkaloids

Triterpene constituents from Euphorbia supina

https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_5/b_fdi_08-09/09561.pdf

J. Vaquette

Papers

Alcaloides d'Araliopsis soyauxii. Isolement d'un nouvel alcaloide, l'Araliopsine

[Study of the constituents of the trunk bark of Zanthoxylum decaryi H. Perrier (Rutaceae). I. Non-alkaloid constituents].