Jack Bergman

TL;DR: The results in conjunction with those of previous studies in squirrel monkeys reveal a close correspondence between the relative potencies of cocaine and related drugs for maintaining i.v. self-administration and for increasing rates of schedule-controlled responding, suggesting that the reinforcing and psychomotor-stimulant effects of the drugs are mediated similarly.

TL;DR: Binding of [3H]cocaine was NaCl-dependent, with specific binding reduced by 72% when NaCl (100 mM) was omitted from the incubation medium, and dopamine was considerably more potent than either norepinephrine or serotonin.

TL;DR: The results show that self-administration of cocaine can be comparably modified by drugs that selectively block dopamine D1 or D2 receptors, and a 3 to 6-fold increase in dose was necessary to restore optimal performances.

TL;DR: The results combined with previous studies demonstrate a close correspondence between the potencies of 15 different drugs for producing cocaine-like behavioral effects and for displacing specifically bound [3H]cocaine in caudate-putamen.

TL;DR: D(2) receptor-related neuronal mechanisms may be especially important in mediating the abuse-related effects of cocaine and have prominent reinforcing effects and enhance the effects of self- Administered cocaine in rats with extensive cocaine self-administration experience.