Jack Y. Vanderhoek

TL;DR: 15-hydroxy-5,8,11,13-eicosatetraenoic acid can regulate the formation of these vasoactive and inflammatory mediators intracellularly.

TL;DR: With a clinically relevant canine model of 10 minutes of cardiac arrest, resuscitation with 21% versus 100% inspired O2 resulted in lower levels of oxidized brain lipids and improved neurological outcome measured after 24 hours of reperfusion, casting further doubt on the appropriateness of present guidelines that recommend the indiscriminate use of 100% ventilatory O2 for undefined periods during and after resuscitation from cardiac arrest.

TL;DR: The present findings indicate that peripheral cells, in spite of their capacity to synthesize cholesterol, depend on exogenous cholesterol for the maintenance of normal levels and it is suggested that the native cholesterol "acceptor" in the lipoprotein-depleted serum is an apolipoprotein which under the experimental conditions can form a complex with phospholipids and might also represent the physiological cholesterol " acceptor", in peripheral lymph.

TL;DR: The high degree of selectivity of the 15-hydroxy derivative of eicosatetraenoic acid makes it the most suitable inhibitor so far discovered for studying the functions of the platelet lipoxygenase system.

TL;DR: In this paper, the authors found that onion and garlic oils were significantly more effective in inhibiting the platelet oxygenases than the oxygenases from the vesicular gland and that these oils suppressed the soybean lipoxygenase-catalyzed oxygenation of AA.