Jae Chan Ryu

TL;DR: It is demonstrated that SESN2 (sestrin 2), known as stress-inducible protein, suppresses prolonged NLRP3 inflammasome activation by clearance of damaged mitochondria through inducing mitophagy in macrophages, defining a unique regulatory mechanism of mitophagic activation for immunological homeostasis that protects the host from sepsis.

TL;DR: In this article, the authors outline protocols for the preparation of a rhodamine-based HOCl probe, as well as applications thereof, with which to detect HOCl in living cells and organisms.

TL;DR: A novel finding of distinctive innate immunity of the nose and lungs, respectively, which trigger AR and AA is described, by showing the critical role of HDM-induced TLR activation via dual oxidase 2-mediated reactive oxygen species.

TL;DR: The far-red-emitting fluorescence probe 1, containing a rhodamine derivative and a hydrazide reactive group, was developed for peroxynitrite detection and imaging and was successfully utilized to detect exogenous and endogenous peroxlynitrite in HeLa and RAW 264.7 cells.

TL;DR: The study reveals previously unknown mechanisms and physiological role of neutrophil pyroptosis during P. aeruginosa lung infection and may explain the causes of acute and/or chronic infectious diseases discovered in immune-compromised patients.