Synthesis of 3-Deoxy Glycals via Tandem Metathesis Sequences and Their Use in an Intermolecular Heck Arylation†

Synthesis of 2-thia-4-azabicyclo[3.3.1]non-3-en-3-amine – bridged nitric oxide synthase inhibitor with enhanced lipophilicity

Application of the Ferrier rearrangement led to a novel carbohydrate based synthetic route to 4-aminohexenoic acid viz. (R) and (S)-vigabatrin. The potential of D- glucose or D-galactose as the chiral starting materials for the synthesis of (R) and (S)- vigabatrin has been explored.

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Jaimala S. Aidhen

Papers

Towards a synthesis of vigabatrin using glycal chemistry.