3.2.3. Hydroformylation 2467 3.2.4. Dimerization 2468 3.2.5. Oxidative Cleavage and Ozonolysis 2469 3.2.6. Metathesis 2470 4. Terpenes 2472 4.1. Pinene 2472 4.1.1. Isomerization: R-Pinene 2472 4.1.2. Epoxidation of R-Pinene 2475 4.1.3. Isomerization of R-Pinene Oxide 2477 4.1.4. Hydration of R-Pinene: R-Terpineol 2478 4.1.5. Dehydroisomerization 2479 4.2. Limonene 2480 4.2.1. Isomerization 2480 4.2.2. Epoxidation: Limonene Oxide 2480 4.2.3. Isomerization of Limonene Oxide 2481 4.2.4. Dehydroisomerization of Limonene and Terpenes To Produce Cymene 2481

Chemical Routes for the Transformation of Biomass into Chemicals

Changes in body temperature after administration of adrenergic and serotonergic agents and related drugs including antidepressants: II.

Effect of Nicotinamide and Urea on the Solubility of Riboflavin in Various Solvents

The purpose of this study was to evaluate the specifically targeted efficiency of budesonide loaded PLGA nanoparticles for the treatment of inflammatory bowel disease (IBD). The nanoparticles were prepared by an oil/water (O/W) emulsion evaporation technique. The nanoparticles were characterized for their size, shape and in vitro drug release profile. Solid state characterization was carried out by differential scanning calorimetry (DSC) and X-ray Power diffraction (XPRD). In order to evaluate the targeted efficiency of nanoparticles, a particle localization study in the healthy and in the inflamed colon was determined in vivo. These data were complemented by cryo-sections. Nanoparticles were 200 ± 05 nm in size with a smooth and spherical shape. The encapsulation efficiency was around 85 ± 3.5%, which was find-out by both, direct and indirect methods. Release of budesonide from the nanoparticles showed a biphasic release profile with an initial burst followed by sustained release. XPRD data revealed that the drug in the polymer matrix existed in crystalline state. Nanoparticles accumulation in inflamed tissues was evaluated by in-vivo imaging system and it was found that particles are accumulated in abundance at the site of inflammation when compared to the healthy group. The study demonstrates that the budesonide loaded PLGA nanoparticles are an efficient delivery system for targeted drug delivery to the inflamed intestinal mucosa.

Budesonide Loaded PLGA Nanoparticles for Targeting the Inflamed Intestinal Mucosa—Pharmaceutical Characterization and Fluorescence Imaging

Catalytic Effect of Buffers on Degradation of Penicillin G in Aqueous Solution

Synthesis and structure-activity relationships of selected isomeric oxime O-ethers as anticholinergic agents.

Phytochemical investigation of Amphipterygium adstringens.

Anticholinergic Heterocyclic Ketoximino-Ethers and -Esters

Synthesis of oxime esters and ethers as potential psychotropic agents

Synthesis of some disubstituted cyanoacetamides as potential anticonvulsants.

Jaime N. Delgado

Papers

Synthesis and structure-activity relationships of selected isomeric oxime O-ethers as anticholinergic agents.

Phytochemical investigation of Amphipterygium adstringens.

Anticholinergic Heterocyclic Ketoximino-Ethers and -Esters

Synthesis of oxime esters and ethers as potential psychotropic agents

Synthesis of some disubstituted cyanoacetamides as potential anticonvulsants.