Showing papers by "Jaishree Jagirdar published in 2009"
TL;DR: Mast cells appear to be concentrated in the lesional small-airway subepithelium in obliterative bronchiolitis, compared with asthma/emphysema, and the possible role of c-KIT inhibitors such as imatinib (Gleevec) in the progression of fibrosis preceding the development of obliterative bronzeitis is discussed.
Abstract: Context.—The mechanism of fibrosis is not clear in patients with obliterative bronchiolitis after a remote injury. Immune-mediated progression may be a reason. c-KIT (CD117)–positive mast cells have been associated with chronic fibrosing diseases and may potentially be treated with imatinib (Gleevec), a c-KIT blocker. Objective.—To evaluate the role of mast cells in fibrosis associated with obliterative bronchiolitis. Design.—Four cases of obliterative bronchiolitis (household cleaner exposure, ammonia exposure, idiopathic, and posttransplantation) were compared with asthma/emphysema. Small and large airways were stained for CD20, CD3, CD4, CD8, CD117, CD34, CD25, stem cell factor (c-KIT ligand) and with toluidine blue, hematoxylin-eosin, and trichrome. c-KIT (CD117)–stained slides were digitally scanned with Aperio ScanScope and stained cells within the epithelium and subepithelium of small and large airways were counted (per millimeter of basement membrane). Results.—Mast cells were concentrate...
16 citations