J
James F. Callahan
Researcher at GlaxoSmithKline
Publications - 66
Citations - 5179
James F. Callahan is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Checklist & Epoxide hydrolase 2. The author has an hindex of 25, co-authored 66 publications receiving 4746 citations. Previous affiliations of James F. Callahan include Nycomed.
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Journal ArticleDOI
SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.
Gareth J. Inman,Francisco J. Nicolás,James F. Callahan,John D. Harling,Laramie Mary Gaster,Alastair D. Reith,Nicholas J. Laping,Caroline S. Hill +7 more
TL;DR: It is demonstrated that SB-431542 is a selective inhibitor of endogenous activin and TGF-beta signaling but has no effect on BMP signaling.
Journal ArticleDOI
Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542
Nicholas J. Laping,Eugene T. Grygielko,A. Mathur,S. Butter,J. Bomberger,C. Tweed,W. Martin,James A. Fornwald,Ruth Lehr,John D. Harling,Laramie Mary Gaster,James F. Callahan,Barbara A. Olson +12 more
TL;DR: Data indicate that some matrix markers that are stimulated by TGF-beta1 are mediated via the p38 MAPK pathway, whereas others seem to be activated via ALK5 signaling independent of the p 38 MAPK pathways.
Journal ArticleDOI
Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).
James F. Callahan,Joelle Lorraine Burgess,James A. Fornwald,Laramie Mary Gaster,John D. Harling,Harrington Frank Peter,Jag Paul Heer,Chet Kwon,Ruth Lehr,A. Mathur,Barbara A. Olson,Joseph Weinstock,Nicholas J. Laping +12 more
TL;DR: Optimization of the triarylimidazole hit 8 gave the selective inhibitor 14, which inhibits TGF-beta1-induced fibronectin mRNA formation while displaying no measurable cytotoxicity in the 48 h XTT assay.
Journal ArticleDOI
Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of iκB kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell proliferation
Patricia L. Podolin,James F. Callahan,Brian Bolognese,Yue H. Li,Karey Carlson,T. Gregg Davis,Geoff W. Mellor,Christopher J. Evans,Amy K. Roshak +8 more
TL;DR: Results suggest that reduction of proinflammatory mediators and inhibition of antigen-induced T cell proliferation are mechanisms underlying the attenuation of CIA by the IKK-2 inhibitor, TPCA-1.
Journal ArticleDOI
Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats
Maxine Gowen,George B. Stroup,R.A. Dodds,Ian E. James,Bart J. Votta,Brian R. Smith,Pradip K. Bhatnagar,Lago Amparo M,James F. Callahan,Eric G. Delmar,Michael A. Miller,Edward F. Nemeth,John Fox +12 more
TL;DR: It is demonstrated that an increase in endogenous PTH secretion, induced by antagonism of the parathyroid cell Ca(2+) receptor with a small molecule, leads to a dramatic increase in bone turnover, and it is suggested that a novel approach to the treatment of osteoporosis is suggested.