J
James P. Pearson
Researcher at University of Rochester
Publications - 20
Citations - 9317
James P. Pearson is an academic researcher from University of Rochester. The author has contributed to research in topics: Autoinducer & Quorum sensing. The author has an hindex of 14, co-authored 20 publications receiving 8789 citations. Previous affiliations of James P. Pearson include University of Iowa & Pearson Education.
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Journal ArticleDOI
The involvement of cell-to-cell signals in the development of a bacterial biofilm
David G. Davies,Matthew R. Parsek,Matthew R. Parsek,Matthew R. Parsek,James P. Pearson,James P. Pearson,James P. Pearson,Barbara H. Iglewski,Barbara H. Iglewski,Barbara H. Iglewski,J. W. Costerton,J. W. Costerton,J. W. Costerton,E. P. Greenberg,E. P. Greenberg,E. P. Greenberg +15 more
TL;DR: The involvement of an intercellular signal molecule in the development of Pseudomonas aeruginosa biofilms suggests possible targets to control biofilm growth on catheters, in cystic fibrosis, and in other environments where P. aerug inosaBiofilms are a persistent problem.
Journal ArticleDOI
Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa
Everett C. Pesci,Jared B. J. Milbank,James P. Pearson,Susan L. McKnight,Andrew S. Kende,E. Peter Greenberg,Barbara H. Iglewski +6 more
TL;DR: The demonstration that 2-heptyl-3-hydroxy-4-quinolone can function as an intercellular signal sheds light on the role of secondary metabolites and shows that P. aeruginosa cell-to-cell signaling is not restricted to acyl-homoserine lactones.
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Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes.
TL;DR: The roles of the rhl and las quorum-sensing systems in virulence gene expression are characterized and RNA analysis of the wild-type strain revealed that rhlAB is organized as an operon.
Journal ArticleDOI
Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes
James P. Pearson,K M Gray,Luciano Passador,Kenneth D. Tucker,Anatol Eberhard,Barbara H. Iglewski,E. P. Greenberg +6 more
TL;DR: In this article, a quantitative bioassay for PAI was developed by cloning a lasB::lacZ fusion and a lasR gene under control of the lac promoter in Escherichia coli.
Journal ArticleDOI
Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa.
TL;DR: The data indicate that lasR and rhlR are expressed in a growth-dependent manner, with activation of each gene occurring during the last half of log-phase growth, and shows that the las system exerts two levels of control on RhlR, transcriptional and posttranslational.