J
James Rasmussen
Researcher at Harvard University
Publications - 8
Citations - 203
James Rasmussen is an academic researcher from Harvard University. The author has contributed to research in topics: Carboxypeptidase & Binding site. The author has an hindex of 4, co-authored 8 publications receiving 196 citations.
Papers
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Journal ArticleDOI
Mechanism of penicillin action: penicillin and substrate bind covalently to the same active site serine in two bacterial D-alanine carboxypeptidases
TL;DR: This study directly proves that penicillin acylates the active site of twoPenicillin-sensitive enzymes, D-alanine carboxypeptidases from Bacillus stearothermophilus and Bacillus subtilis and suggests that these two groups of enzymes are evolutionally related.
Journal ArticleDOI
Utilization of a depsipeptide substrate for trapping acyl—enzyme intermediates of penicillin-sensitive D-alanine carboxypeptidases
TL;DR: The penicillin-sensitive D-alanine carboxypeptidases of Bacillus subtilis, Escherichia coli, and Staphylococcus aureus catalyzed the hydrolysis of the D-lactic acid residue from the depsipeptide diacetyl-L-lysyl- D-alanyl-D- lactic acid.
Patent
Methods and compositions for treatment of autoimmune diseases
TL;DR: In this paper, the authors present methods and compositions for treating autoimmune diseases and other unwanted immune reactions comprising administering a copolymer that binds to one or more HLA-DQ molecules and modulates DQ-restricted T cell responses.
Patent
Random copolymer compositions for treating unwanted immune response
James Rasmussen,Jianxin Zhang,Sam Baldwin,Eric Zanelli,Bei Yu,Dustin Bonnin,Keith Johnson,Jeff Krieger +7 more
TL;DR: In this paper, the authors have proposed methods and kits for treating or preventing disease through the administration of random copolymers, which are used for the treatment of autoimmune diseases, such as multiple sclerosis, and for treatment regimen comprising formulations that are administered at intervals greater than 24 hours.
Patent
Methods of treating unwanted immune response with random copolymers
James Rasmussen,Jianxin Zhang,Sam Baldwin,Eric Zanelli,Bei Yu,Dustin Bonnin,Keith Johnson,Jeff Krieger +7 more
TL;DR: In this paper, the authors have proposed methods and kits for treating or preventing disease through the administration of random copolymers, which are used for the treatment of autoimmune diseases, such as multiple sclerosis, and for treatment regimen comprising formulations that are administered at intervals greater than 24 hours.