J
Jamil Nehme
Researcher at University Medical Center Groningen
Publications - 7
Citations - 1361
Jamil Nehme is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Senescence & Gene. The author has an hindex of 3, co-authored 4 publications receiving 681 citations. Previous affiliations of Jamil Nehme include Lebanese University.
Papers
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Journal ArticleDOI
Hallmarks of Cellular Senescence.
TL;DR: The molecular regulators of senescence phenotypes and how they are used for identifying senescent cells in vitro and in vivo are described and the importance that these levels of regulations have in the development of therapeutic targets is highlighted.
Journal ArticleDOI
Cellular senescence as a potential mediator of COVID-19 severity in the elderly
Jamil Nehme,Jamil Nehme,Michela Borghesan,Sebastian Mackedenski,Thomas G. Bird,Thomas G. Bird,Marco Demaria +6 more
TL;DR: How cellular senescence—a state of stable growth arrest characterized by pro‐inflammatory and pro‐disease functions—can hypothetically be a contributor to COVID‐19 pathogenesis, and a potential pharmaceutical target to alleviate disease severity is discussed.
Journal ArticleDOI
Caloric restriction and cellular senescence
TL;DR: Calorie restriction without malnutrition is currently the most effective non-genetic intervention to delay aging phenotypes, and how these events can interfere with the induction of cellular senescence is defined.
Journal ArticleDOI
The effects of macronutrients metabolism on cellular and organismal aging
TL;DR: In this article , the authors summarize the current knowledge on the molecular and cellular events associated with carbohydrate, lipid and protein metabolism, and define how macronutrients can regulate induction or prevention of cellular senescence.
Book ChapterDOI
Molecular mechanisms of cellular senescence
TL;DR: In this article, the authors discuss the mechanisms regulating induction and establishment of various senescence programs, with particular emphasis on their biological heterogeneity and functional implications, and discuss the mechanism that contributes to tissue remodeling and regeneration.