J
Jan Lanz
Researcher at Zürcher Fachhochschule
Publications - 2
Citations - 53
Jan Lanz is an academic researcher from Zürcher Fachhochschule. The author has contributed to research in topics: Allosteric regulation & Fragment-based lead discovery. The author has an hindex of 2, co-authored 2 publications receiving 47 citations. Previous affiliations of Jan Lanz include Zurich University of Applied Sciences/ZHAW.
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Merging allosteric and active site binding motifs : de novo generation of target selectivity and potency via natural-product-derived fragments
Jan Lanz,Rainer Riedl +1 more
TL;DR: This work validate natural‐product‐derived fragments (NPDFs) as excellent molecular seeds for the targeted de novo discovery of lead structures for the modulation of therapeutically relevant proteins.
Journal ArticleDOI
Targeted Polypharmacology: Discovery of a Highly Potent Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-10/-13 Inhibitor
TL;DR: The discovery of a very potent and selective non-hydroxamate MMP-10/-13 inhibitor that enables this compound to decipher disease causing MMP networks and to generate new treatment options through targeted polypharmacology.