Jane R. Noble

TL;DR: It is reported here that ALT cells contain a novel promyelocytic leukemia (PML) body (ALT-associated PML body, APB), which are large donut-shaped nuclear structures containing PML protein, telomeric DNA, and the telomere binding proteins human telomerre repeat binding factors 1 and 2.

TL;DR: It is concluded that a human protein similar to the fish hormone is expressed in multiple tissues rather than by a specialized endocrine organ.

TL;DR: The extended period of growth observed in postselection HMECs is associated with hypermethylation of the p16ink4 CpG island and loss of p16INK4 expression, indicating that postselectionHMECs have sustained an epigenetic alteration.

TL;DR: It is shown here that knockout or knockdown of ATRX in mortal cells or immortal telomerase-positive cells is insufficient to activate ALT, and the first direct, functional evidence that ATRx represses ALT is provided, which indicates that loss of ATrX function cooperates with one or more as-yet unidentified genetic or epigenetic alterations to activated ALT.

TL;DR: Although SV40-immortalized cells are useful for studies of carcinogenesis, hTERT-imm Mortalized cells retain more properties of normal cells.