J
Janish Kumar
Researcher at University of Hyderabad
Publications - 3
Citations - 40
Janish Kumar is an academic researcher from University of Hyderabad. The author has contributed to research in topics: Gene & Selectivity. The author has an hindex of 2, co-authored 2 publications receiving 21 citations.
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Synthesis of 1-benzyl-1H-benzimidazoles as galectin-1 mediated anticancer agents
Nerella Sridhar Goud,S. Mahammad Ghouse,Jatoth Vishnu,Daipule Komal,Venu Talla,Ravi Alvala,Jakkula Pranay,Janish Kumar,Insaf A. Qureshi,Mallika Alvala +9 more
TL;DR: Induction of apoptosis was confirmed by morphological changes like cell shrinkage, blebbing and cell wall deformation, dose dependent increase in the mitochondrial membrane potential (ΔΨm) and ROS levels, and dose dependent decrease in Gal-1 protein levels provesGal-1 mediated apoptosis by 6g.
Journal ArticleDOI
Designing of Nucleocapsid Protein Based Novel Multi-epitope Vaccine Against SARS-COV-2 Using Immunoinformatics Approach.
TL;DR: The results advocate that the designed vaccine candidate could be an effective and promising weapon to fight with COVID-19 infection worldwide.
Journal ArticleDOI
Binary Quantitative activity-activity relationship (QAAR) studies to explore selective HDAC8 inhibitors: In light of mathematical models, DFT-based calculation and molecular dynamic simulation studies
Sk. Abdul Amin,Janish Kumar,Samima Khatun,Sanjib Kr. Das,Insaf A. Qureshi,Tarun Jha,Shovanlal Gayen +6 more
TL;DR: In this article , a mathematical framework has been constructed to understand the important molecular fragments responsible for HDAC8 selectivity over HDAC1, 2 and 3, and the possible binding mechanism of in-house compounds with HDAC 8 by molecular dynamic simulation.