Jason S. White

TL;DR: Generation of stable cell lines from head and neck squamous cell carcinomas is biased towards tumors with a poor prognosis, indicating that establishment of HNSCC cell lines enriches the resources available for cancer research.

TL;DR: It is hypothesised that HPV infection may represent an early event in the HNSCC carcinogenic process, thus suggesting a distinct molecular pathway, and lack the genetic alterations which are common in other tumours.

TL;DR: All cell lines with distal 11q loss exhibited a diminished DNA damage response, as measured by a decrease in the size and number of γ‐H2AX foci and increased chromosomal instability following treatment with ionizing radiation.

TL;DR: It is shown that even transient inhibition of ATM kinase for 1 hour, initiated 15 minutes after cellular irradiation, resulted in an accumulation of persistent chromosome aberrations and increased cell death, which suggests that A-T fibroblasts have adapted to the loss of ATM and have alternative mechanisms to initiate SCE.

TL;DR: It is proposed that an essential, yet previously undescribed, role for ATM kinase in suppressing chromosomal instability is revealed and it is suggested that irreversible chromosome damage accumulates very rapidly when ATM Kinase activity is transiently inhibited following irradiation.