Showing papers by "Jatinder Kaur published in 2002"

Thermal/microwave assisted synthesis of substituted tetrahydropyrimidines as potent calcium channel blockers

Abstract: The synthesis of 6-methyl-4-substitutedphenyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid ethyl esters la-h is achieved when aromatic aldehydes, urea and ethyl acetoacetate are condensed in presence of piperidine as catalyst. Similarly, 6-methyl-4-suhstitutedphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid ethyl esters 2a-e are formed when aromatic aldehydes, thiourea and ethyl acetoacetate are condensed in presence of piperidine as catalyst. 2a-e give 6-methyl-4-substitutcdphenyl-2-S-alkyl-1,4-dihydropyrimidin-5-carboxylic acid ethyl esters 3a-h when they are heated with a suitable alkylating agent. Potent Ca 2 + channel antagonistic activity has been found in some of the compounds synthesized.

Thermal/Microwave Assisted Synthesis of Substituted Tetrahydropyrimidines as Potent Calcium Channel Blockers.

Abstract: The synthesis of 6-methyl-4-substitutedphenyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid ethyl esters la-h is achieved when aromatic aldehydes, urea and ethyl acetoacetate are condensed in presence of piperidine as catalyst. Similarly, 6-methyl-4-suhstitutedphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid ethyl esters 2a-e are formed when aromatic aldehydes, thiourea and ethyl acetoacetate are condensed in presence of piperidine as catalyst. 2a-e give 6-methyl-4-substitutcdphenyl-2-S-alkyl-1,4-dihydropyrimidin-5-carboxylic acid ethyl esters 3a-h when they are heated with a suitable alkylating agent. Potent Ca 2 + channel antagonistic activity has been found in some of the compounds synthesized.