ABSTRACT We employed density functional theory to inspect the impact of Ir-decoration on the sensing performance of a GaN nanotube (GaNNT) in the detection of mesalamine (MA). The interaction of the pristine GaNNT with MA was found to be weak, and the sensing response was approximately 4.3. Decorating an Ir atom into the GaNNT surface increased the adsorption energy (E ad) of MA from −6.7 to −23.8 kcal/mol. The sensing response significantly increased to 89.4 after decorating the Ir atom. A short recovery time of 22.0 s was found for the desorption of MA from the surface of the Ir-decorated GaNNT at 298 K. The water solvent reduced E ad of MA to −19.8 kcal/mol. Thus, we concluded that the Ir-decorated GaNNT might be a highly sensitive MA sensor with a short recovery time.

Ir-decorated gallium nitride nanotubes as a chemical sensor for recognition of mesalamine drug: a DFT study

The present study aimed at synthesising chitosan bound ginger nanocarriers for slow and controlled release of the drug 5-amino salicylic acid (5-ASA) against inflammatory bowel diseases (IBD). The chitosan, extracted from naturally occurring biopolymer chitin, was reacted to ginger extract (Zingiber officinale) to prepare chitosan-bounded ginger derived nanocarriers (C-GDNC) and further loaded with 5-ASA drug. The as-obtained drug loaded chitosan coated ginger derived nanocarriers (D-C-GNDC) were studied for controlled release of 5-ASA. In vitro experimental data implied slow and controlled release of 5-ASA and were kinetically justified by applying different kinetic models. The obtained percent drug loading capacity and entrapment efficiency were more than 50%. Various experimental factors affecting swelling controlled drug release of 5-ASA, such as change in pH of release medium, chemical composition of nanocarriers, percent drug loading, and simulated biofluids as release media, were investigated. The prepared nanomaterials were well characterized and examined for chemical stability and in vitro cytotoxicity to check their biocompatible nature. The overall studies concluded that the controlled release of 5-ASA was favourable at the gastrointestinal pH which is desirably beneficial against inflammation of bowl.

Functionalization of ginger derived nanoparticles with chitosan to design drug delivery system for controlled release of 5-amino salicylic acid (5-ASA) in treatment of inflammatory bowel diseases: An in vitro study

Five-aminosalicylic acid (5-ASA) is an anti-inflammatory drug indicated in the treatment of inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. Among the analytical methods of quantification of 5-ASA described in the literature, the High Efficiency Liquid Chromatography stands out, a sensitive technique but with a high cost. In recent years, alternative methods have been developed, presenting efficiency and reduced cost, such as UV/visible spectrophotometric, spectrofluorescent, and electrochemical methods, techniques recommended for the application in quality control and quantification of 5-ASA in pharmaceutical forms and biological fluids. This article aims to review the physicochemical characteristics, pharmacokinetics, mechanisms of action, controlled release systems, and the different analytical and bioanalytical methods for the quantification of 5-ASA.

Characteristics, Properties and Analytical/Bioanalytical Methods of 5-Aminosalicylic Acid: A Review

Abstract We employed density functional B3LYP to inspect the impact of Pd-decoration on an AlP quantum dot (AlPQ) sensing performance in detection of mesalamine (MA) drug. The interaction of the pristine AlPQ with the MA was found to be weak, and the sensing response is about 2.5. Decorating a Pd atom into the AlPQ surface increases the adsorption energy (E ad) of MA from −6.1 to −23.5 kcal/mol. The sensing response significantly rises to 82.7 by Pd-decoration. A short recovery time of 13.3 s is found for the MA desorption from the Pd-decorated AlPQ surface at 298 K. The water solvent reduces E ad of MA to −19.4 kcal/mol. Thus, it suggests that Pd-decorated AlPQ may be highly sensitive MA sensor with a short recovery time. Graphical Abstract

A DFT study on the Pd-decorated AlP quantum dots as chemical sensor for recognition of mesalamine drug

https://iopscience.iop.org/article/10.1088/1757-899X/263/2/022025/pdf

Jayagopal Balaji

Papers

Development and validation of RP-UHPLC procedure for estimation of 5-amino salicyclic acid in 5-amino salicyclic acid rectal suppositories