Metal complexes of Schiff bases synthesized from condensation of an amine with carbonyl compounds are widely used for industrial purposes such as catalysts, pigments and dyes, intermediates in orga...

REVIEW: Biomedical applications of Schiff base metal complexes

Spectroscopic and thermal nonlinearity study of a Schiff base compound

Synthesis, characterization, simulation, DNA binding and anticancer activities of Co(II), Cu(II), Ni(II) and Zn(II) complexes of a Schiff base containing o-hydroxyl group nitrogen ligand

Synthesis, characterization, electrochemical behavior, molecular simulation studies and in vitro toxicity assessment of new metal Schiff base complexes derived from 3‑methoxy-2‑hydroxy-benzaldehyde and allylamine

Some Theoretical Aspects of Enzyme Mechanisms: Mechanical Force, Hydration, and Conformational Fluctuations in Enzymic Catalysis (R. Lumry). Complexation and Catalysis in Biology (R.J.P. Williams). Mechanistic Role of Biotin in Enzymatic Carboxylation Reactions (A.S. Mildvan, D.C. Fry, and E.H. Serpersu). Thiamin-Dependent Reactions (Mechanisms) (C.J. Gubler). Allostery and Non-Michaelis-Menten Behavior: Glycogen Phosphorylase and Glycogen Synthetase (N.B. Madsen). Proteases-Structures and Mechanisms: Calcium-Activated Neutral Protease (K. Imahori, K. Suzuki, and S. Kawashima). Dehydrogenases-Structure and Catalytic Mechanisms: Glutamate Dehydrogenase (Bovine Liver) (R.F. Colman). Dihydrofolate Reductase (J.F. Morrison). 2-Oxoacid Dehydrogenases (M. Hamada and H. Takenaka). Flavoprotein Catalysis: Old Yellow Enzyme (L.M. Schopfer and V. Massey). D-Amino Acid Oxidase (K. Yagi). Cytochrome c, Quinone, and Cytochrome P-450 Reductases (M.S. Johnson and S.A. Kuby). Activated Oxygen Reactions: Dioxygenases and Monooxygenases (S. Yamamoto and Y. Ishimura). ATP-ases, Nucleotide Binding Carriers, and Nucleotidyl Transferases: Ca2+, Mg2+-ATPase (Microsomal) (H. Takenaka, M. Sumida, and M. Hamada). Mechanistic and Energetic Aspects of Carrier Catalysis-Exemplified with Mitochondrial Translocators (M. Klingenberg). Terminal Deoxynucleotidyl Transferase (M.J. Modak and V.N. Pandey). Phosphotransferases-Structure and Mechanisms: Adenylate Kinase (M. Hamada, H. Takenaka, M. Sumida, and S.A. Kuby). Phosphofructokinase and Fructose 6-Phosphate, 2-Kinase: Fructose 2,6-Bisphosphatase (K. Uyeda). Emden-Meyerhof Reactions-Mechanism of Action: Triose- and Hexose-Phosphate Isomerases (K.UE. Yuksel and R.W. Gracy). Mechanistic Studies of Muscle Aldolase (D.J. Hupe). Metalloenzymes: Mechanism and Structure of Superoxide Dismutases (J.A. Tainer, V.A. Roberts, C.L. Fisher, R.A. Hallewell, and E.D. Getzoff). Hydrolases-Mechanisms: Phospholipases (G. Arthur and P.C. Choy). Esterases (Including Choline Esterases) (H. Okuda). Lipases (H. Okuda). Index.

Mechanism of enzyme action

Mononuclear complex has been used as a building block in the synthesis of homo/hetero binuclear complexes. The complex behaves as a potential metallo-ligand. Its reaction with different metal salts (Ni & Cu) lead to the formation of binuclear complexes. The homo and hetero binuclear oxygen bridged Cu(II) and Ni(II) complexes had been synthesized from the Schiff base ligand derived from 4-chloro-o-phenylenediamine and 3,5-dichloro-2-hydroxyacetophenone. The synthesized complexes have been characterized with the support of more than a few standard physicochemical techniques such as elemental analysis, spectroscopic, thermal, cyclic voltammetry and magnetic moment studies. Spectral analysis exhibits square planer geometry for Cu(II) & Ni(II) mono and binuclear complexes. The antimicrobial results indicate that the homo-binuclear copper complex exhibit more activity than the other mono and binuclear complexes. The Schiff base and their complexes have been screened for their anticancer activity using MCF7 cell line.

/pdf/an-insight-into-antibacterial-and-anticancer-activity-of-4crif1v4lo.pdf

An Insight Into Antibacterial and Anticancer Activity of Homo and Hetero Binuclear Schiff Base Complexes

SYNTHESIS, SPECTROSCOPIC, ANTICANCER, ANTIMICROBIAL AND ANTIOXIDANT STUDIES OF HOMO-BINUCLEAR Cu(II), Co(II), Ni(II) AND Mn(II) COMPLEXES WITH POLYDENTATE SCHIFF BASE LIGAND.

Jayalakshmi Rajendran

Papers

An Insight Into Antibacterial and Anticancer Activity of Homo and Hetero Binuclear Schiff Base Complexes

SYNTHESIS, SPECTROSCOPIC, ANTICANCER, ANTIMICROBIAL AND ANTIOXIDANT STUDIES OF HOMO-BINUCLEAR Cu(II), Co(II), Ni(II) AND Mn(II) COMPLEXES WITH POLYDENTATE SCHIFF BASE LIGAND.