J
Jeff Maltas
Researcher at University of Michigan
Publications - 19
Citations - 420
Jeff Maltas is an academic researcher from University of Michigan. The author has contributed to research in topics: Population & Drug resistance. The author has an hindex of 8, co-authored 18 publications receiving 284 citations. Previous affiliations of Jeff Maltas include Miami University & Cleveland Clinic.
Papers
More filters
Journal ArticleDOI
Pervasive and diverse collateral sensitivity profiles inform optimal strategies to limit antibiotic resistance.
Jeff Maltas,Kevin B. Wood +1 more
TL;DR: An extensive quantitative characterization of collateral effects in Enterococcus faecalis, a gram-positive opportunistic pathogen, reveals a new conceptual strategy for mitigating resistance by balancing short-term inhibition of pathogen growth with infrequent use of drugs intended to steer pathogen populations to a more vulnerable future state.
Posted ContentDOI
UV Sterilization of Personal Protective Equipment with Idle Laboratory Biosafety Cabinets During the Covid-19 Pandemic
Davis T. Weaver,Benjamin D. McElvany,Vishhvaan Gopalakrishnan,Kyle J. Card,Kyle J. Card,Dena Crozier,Andrew Dhawan,Andrew Dhawan,Mina N. Dinh,Emily Dolson,Nathan Farrokhian,Masahiro Hitomi,Emily Ho,Tanush Jagdish,Eshan S. King,Nikhil Krishnan,Gleb Kuzmin,Ju Li,Jeff Maltas,Jinhan Mo,Julia Pelesko,Jessica A. Scarborough,Geoff Sedor,Enze Tian,Gary An,Sean A. Diehl,Jacob G. Scott +26 more
TL;DR: In this study, a procedure by which N95 respirators may be sterilized using ultraviolet (UV) radiation in biosafety cabinets (BSCs) to alleviate the PPE shortage by providing a way to sterilize PPE to allow safe daily re-use is outlined.
Journal ArticleDOI
Population Density Modulates Drug Inhibition and Gives Rise to Potential Bistability of Treatment Outcomes for Bacterial Infections
TL;DR: It is shown that density-dependent growth inhibition is pervasive for commonly used antibiotics, with some drugs showing increased inhibition and others decreased inhibition at high densities, and how time-dependent dosing strategies can mitigate the negative effects of density-dependence.
Posted ContentDOI
Pervasive and diverse collateral sensitivity profiles inform optimal strategies to limit antibiotic resistance
Jeff Maltas,Kevin B. Wood +1 more
TL;DR: An extensive quantitative characterization of collateral effects in E. faecalis, a gram-positive opportunistic pathogen, is provided and optimal drug policies that assign a unique drug to every possible resistance profile are designed.
Posted ContentDOI
Measuring competitive exclusion in non-small cell lung cancer
Nathan Farrokhian,Jeff Maltas,Mina N. Dinh,Arda Durmaz,Patrick Ellsworth,Masahiro Hitomi,Erin McClure,Andriy Marusyk,Artem Kaznatcheev,Artem Kaznatcheev,Jacob G. Scott,Jacob G. Scott +11 more
TL;DR: In this article, the frequency-dependent interactions between a gefitinib resistant non-small cell lung cancer (NSCLC) population and its sensitive ancestor via the evolutionary game assay are measured.