J
Jefferson C. Frisbee
Researcher at University of Western Ontario
Publications - 85
Citations - 2141
Jefferson C. Frisbee is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Skeletal muscle & Microcirculation. The author has an hindex of 26, co-authored 85 publications receiving 2016 citations. Previous affiliations of Jefferson C. Frisbee include Medical College of Wisconsin.
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Impaired NO-dependent dilation of skeletal muscle arterioles in hypertensive diabetic obese Zucker rats
TL;DR: Treatment of cremaster muscles of OZR with the superoxide scavengers polyethylene glycol-superoxide dismutase and catalase improved arteriolar dilation to acetylcholine and sodium nitroprusside and restored flow-induced dilation and microvascular ability to regulate wall shear rate.
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Oxidant stress-induced increase in myogenic activation of skeletal muscle resistance arteries in obese Zucker rats.
TL;DR: This article characterized myogenic activation of skeletal muscle (gracilis) resistance arteries from lean (LZR) and obese Zucker rats (OZR), and found that the arteries from OZR exhibited increased myogenic activity.
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Augmented adrenergic vasoconstriction in hypertensive diabetic obese Zucker rats
TL;DR: The results suggest that the constrictor reactivity of skeletal muscle microvessels in OZR is heightened in response to alpha-adrenergic stimuli and that development of diabetes in OzR may be associated with impaired skeletal muscle perfusion and hypertension due to microvessel hyperreactivity in Response to sympathetic stimulation.
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Remodeling of the skeletal muscle microcirculation increases resistance to perfusion in obese Zucker rats
TL;DR: Developing structural alterations to the skeletal muscle microcirculation in OZR result in elevated vascular resistance, which may, acting in concert with impaired arteriolar reactivity, contribute to blunted active hyperemic responses and compromised performance of in situ skeletal muscle with elevated metabolic demand.
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Low-flow vascular remodeling in the metabolic syndrome X
TL;DR: Results suggest that syndrome X, by reducing hindlimb blood flow, induces a marked remodeling of microcirculation to favor smaller, less distensible vessels, which may result in an architectural limitation of maximum perfusion capacity and may be an important maladaption in the progression of peripheral microvascular disease.