J
Jeffrey Anderson
Researcher at General Atomics
Publications - 4
Citations - 952
Jeffrey Anderson is an academic researcher from General Atomics. The author has contributed to research in topics: Metabotropic receptor & Metabotropic glutamate receptor 2. The author has an hindex of 4, co-authored 4 publications receiving 919 citations.
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Journal ArticleDOI
Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268.
TL;DR: It is indicated that systemic ketamine increases both glutamate and DA release in mPFC and that the effect on glutamate can be blocked by stimulating mP FC group II mGluR receptors.
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3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine: A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity
Nicholas D. P. Cosford,Lida Tehrani,Jeffrey Roger Roppe,Edwin J. Schweiger,Nicholas D. Smith,Jeffrey Anderson,Linda J. Bristow,Jesse Brodkin,Xiaohui Jiang,Ian A. McDonald,Sara Rao,Mark S. Washburn,Mark A. Varney +12 more
TL;DR: Seeking to improve the properties of 2-Methyl-6-(phenylethynyl)pyridine led to the synthesis of compound 9, a highly selective mGlu5 receptor antagonist that is 5-fold more potent than 3 in the rat fear-potentiated startle model of anxiety.
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Discovery of Novel Heteroarylazoles That Are Metabotropic Glutamate Subtype 5 Receptor Antagonists with Anxiolytic Activity
Jeffrey Roger Roppe,Nicholas D. Smith,Dehua Huang,Lida Tehrani,Bowei Wang,Jeffrey Anderson,Jesse Brodkin,Janice Chung,Xiaohui Jiang,Christopher D. King,Benito Munoz,Mark A. Varney,Petpiboon Peppi Prasit,Nicholas D. P. Cosford +13 more
TL;DR: Compound 47 is active in the rat fear-potentiated startle (FPS) model of anxiety with ED(50) = 5.4 mg/kg (po) when dosed acutely and rapidly tolerate on repeated dosing.
Journal ArticleDOI
Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists
Peter C. Chua,Johnny Yasuo Nagasawa,Leo Bleicher,Benito Munoz,Edwin J. Schweiger,Lida Tehrani,Jeffrey Anderson,Merryl Cramer,Janice Chung,Mitchell D. Green,Christopher D. King,Grace Reyes-Manalo,Nicholas D. P. Cosford +12 more
TL;DR: Structure-activity relationship studies leading to the discovery of novel mGlu5 receptor antagonists show high in vitro potency, have good in vivo receptor occupancy, and a reasonable intravenous pharmacokinetic profile.