The present invention concerns novel stent apparatuses for use in treating lesions at or near the bifurcation point in bifurcated cardiac, coronary, renal, peripheral vascular, gastrointestinal, pulmonary, urinary and neurovascular vessels and brain vessels More particularly, the invention concerns a stent apparatus with at least one side opening which may further comprise an extendable stent portion laterally extending from the side opening and at least partly in registry with the wall of the side opening Devices constructed in accordance with the invention include, singularly or in combination, a main expandable stent comprising at least one substantially circular side opening located between its proximal and distal end openings, which side opening may further comprise an expandable portion extending radially outward from the edges of the side opening; and a branch stent comprising proximal and distal end openings and which may further comprise a contacting portion at its proximal end, and which may optionally be constructed to form either a perpendicular branch or a non-perpendicular branch when inserted through a side opening of the main stent The stents of the invention are marked with, or at least partially constructed of, a material which is imageable during intraluminal catheterization techniques, most preferably but not limited to ultrasound and x-ray

Extendible Stent Apparatus

The present invention relates to a method of treating cancer in a mammal by administration of 4-quinazolinamines and at least one additional anti-neoplastic compound. In particular, the method relates to a methods of treating cancers by administration of N-{3-chloro-4-[(3-fluorobenzyl) oxy]phenyl}-6-[5-({[2-(methanesulphonyl) ethyl]amino} methyl)-2-furyl]-4-quinazolinamine and salts and solvates thereof in combination with at least one additional anti-neoplastic compound.

Cancer treatment method

The present invention is directed to a stent for use in a bifurcated body lumen having a main branch and a side branch. The stent comprises a radially expandable generally tubular stent body having proximal and distal opposing ends with a body wall having a surface extending therebetween. The surface has a geometrical configuration defining a first pattern, and the first pattern has first pattern struts and connectors arranged in a predetermined configuration. The stent also comprises a branch portion comprised of a second pattern, wherein the branch portion is at least partially detachable from the stent body.

Stent with protruding branch portion for bifurcated vessels

A multi-layer vascular therapeutic-containing prosthesis designed and arranged to "pump" the therapeutics into the blood stream.

Intravascular stent pump

A pressure sensing lead, wherein a hollow needle extending from the distal end of the lead is coupled to a pressure transducer. The hollow needle may be coiled and adapted to be screwed into human tissue, for example through the ventricular septum from the right ventricle into the left ventricle of a patient's heart, or through the wall of the heart into the pericardial sac. Alternatively, the hollow needle may be straight and a separate coiled needle mounted around the straight needle may be provided to affix the lead to body tissue. Pressure gradients are communicated from the tip of the hollow needle to its base and applied to the pressure sensor, allowing, for example, left ventricular pressure measurements to be taken from the right ventricle or pericardial sac pressure measurements to be taken from within the heart without the necessity of the pressure sensor itself passing through the heart wall.

Implantable pressure sensor lead

An apparatus for locating a body cavity having a fluctuating fluid pressure by signaling the fluctuating pressure when the cavity is entered and then transporting fluid either into or out of the cavity.

Apparatus for locating body cavities

Apparatus for locating body cavities having signaling indicator

A improved blood flow conduit provided with external inflatable balloons and having rigid end portions for facilitating insertion into blood vessels and means for detecting pulsatile flow in the conduit and excessive pressure in the balloons.

Blood flow conduit

A method of constructing a blood flow conduit provided with external inflatable balloons and having rigid end portions for facilitating insertion into blood vessels and means for detecting pulsatile flow in the conduit and excessive pressure in the balloons.

Jeffrey M. Stupar

Papers

Apparatus for locating body cavities

Apparatus for locating body cavities having signaling indicator

Blood flow conduit

Method of constructing a blood flow conduit