J
Jennifer A. Smith
Researcher at University of California, Santa Barbara
Publications - 5
Citations - 338
Jennifer A. Smith is an academic researcher from University of California, Santa Barbara. The author has contributed to research in topics: Microtubule & Eribulin. The author has an hindex of 5, co-authored 5 publications receiving 299 citations.
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Journal ArticleDOI
Eribulin Binds at Microtubule Ends to a Single Site on Tubulin To Suppress Dynamic Instability
Jennifer A. Smith,Leslie Wilson,Olga Azarenko,Xiaojie Zhu,Bryan M. Lewis,Bruce A. Littlefield,Mary Ann Jordan +6 more
TL;DR: Overall, the results indicate that eribulin binds with high affinity to microtubule plus ends and thereby suppresses dynamic instability.
Journal ArticleDOI
Structural basis for induction of peripheral neuropathy by microtubule-targeting cancer drugs
Jennifer A. Smith,Barbara S. Slusher,Krystyna M. Wozniak,Mohamed H. Farah,Gregoriy Smiyun,Leslie Wilson,Stuart C. Feinstein,Mary Ann Jordan +7 more
TL;DR: Results suggest that paclitaxel and ixabepilone, which bind along the lengths and stabilize microtubules, inhibit kinesin- based axonal transport, but not dynein-based transport, whereas the microtubule-destabilizing drugs, eribulin and vincristine, have significantly less effect on all micro Tubule-based axonal Transport.
Journal ArticleDOI
Effects of eribulin on microtubule binding and dynamic instability are strengthened in the absence of the βIII tubulin isotype.
Leslie Wilson,Manu Lopus,Herbert P. Miller,Olga Azarenko,Stephen Riffle,Jennifer A. Smith,Mary Ann Jordan +6 more
TL;DR: aberibulin suppressed the dynamic instability behavior of βIII-depleted microtubules more strongly than and in a manner different from that of micro Tubules containing βIII tubulin.
Book ChapterDOI
Determination of Drug Binding to Microtubules In Vitro
TL;DR: Detailed instructions for assessing binding stoichiometry and affinity to assembled unstabilized microtubules using radiolabeled drug are presented and aspects of the interactions with microtubule that may alter the experimental design of the drug-binding experiments are discussed.
Journal ArticleDOI
Meeting Report: Inaugural Chemotherapy-Induced Peripheral Neuropathy Symposium - Santa Barbara, CA, February 2015.
TL;DR: This conference was the first of its kind to bring together a wide range of clinicians, researchers, and industry professionals to address the potential causes, preventions, and treatments forChemotherapy-induced peripheral neuropathy.