Jennifer E. Quinn

TL;DR: It is concluded that a loss of BRCA1 function is associated with sensitivity to DNA-damaging chemotherapy and may also be associated with resistance to spindle poisons.

TL;DR: In this paper, the role played by BRCA1 in mediating the phenotypic response to a range of chemotherapeutic agents commonly used in cancer treatment was evaluated, and it was shown that BRCa1 mediates sensitivity to apoptosis induced by antimicrotubule agents but conversely induces resistance to DNA-damaging agents.

TL;DR: The role of BRCA1 in relation to transcriptional regulation and in particular how this impacts upon cell cycle control is focused on.

TL;DR: Evidence is provided that inhibition of endogenous BRCA1 expression in ovarian cancer cell lines results in increased sensitivity to platinum therapy and decreased sensitivity to antimicrotubule agents and provides evidence to support a role for BRCa1 mRNA expression as a predictive marker of survival in sporadic epithelial ovarian cancer.

TL;DR: BRCA1 alters the response of breast cancer cells to antiestrogen therapy by directly modulating ERalpha expression, and this work examined a possible mechanism for the observed ER alpha-negative phenotype of BRCA 1-mutant tumors.