Jennifer L. Hall

TL;DR: It is now clear that metabolic interventions aimed at enhancing glucose utilisation and pyruvate oxidation at the expense of fatty acid oxidation is a valid therapeutic approach to the treatment of myocardial ischaemia.

TL;DR: The major derangement in carbohydrate metabolism in diabetic myocardium was not in glycolysis but, rather, in pyruvate oxidation, as reflected in increased lactate production, and depressed lactate uptake and pyruVate dehydrogenase activity under control and dobutamine conditions.

TL;DR: The increased cardiac work following dobutamine infusion is accompanied by a decrease in malonyl CoA levels and an increase in fatty acid uptake, however, the decrease in Malone CoA cannot be explained by a decreases in ACC activity.

TL;DR: In this article, the effect of insulin on the fate of glucose and contractile function in isolated working hypertrophied hearts from rats with an aortic constriction (n = 27) and control hearts from s...

TL;DR: Glycolytic metabolism is not impaired in hyperglycemic diabetic swine after 1 month of the disease when compared with that in normoglycemic nondiabetic animals, and insulin-regulatable glucose transporter was measured in left ventricular biopsies.