J
Jennifer L. Thompson
Researcher at University of California, Irvine
Publications - 2
Citations - 4751
Jennifer L. Thompson is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Amyloid & Fibril. The author has an hindex of 2, co-authored 2 publications receiving 4506 citations.
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Journal ArticleDOI
Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis
Rakez Kayed,Elizabeth Head,Jennifer L. Thompson,Theresa M. McIntire,Saskia Milton,Carl W. Cotman,Charles G. Glabe +6 more
TL;DR: It is shown that all of the soluble oligomers tested display a common conformation-dependent structure that is unique to soluble oligomer regardless of sequence, suggesting they share a common mechanism of toxicity.
Journal ArticleDOI
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers
Rakez Kayed,Elizabeth Head,Floyd Sarsoza,Tommy Saing,Carl W. Cotman,Mihaela Necula,Lawrence Margol,Jessica W. Wu,Leonid Breydo,Jennifer L. Thompson,Suhail Rasool,Tatyana Gurlo,Peter C. Butler,Charles G. Glabe +13 more
TL;DR: Since the fibril specific antibodies are conformation dependent, sequence-independent, and recognize epitopes that are distinct from those present in prefibrillar oligomers, they may have broad utility for detecting and characterizing the accumulation of amyloid fibrils and fibrillare type oligomers in degenerative diseases.