J
Jens Aberle
Researcher at University of Hamburg
Publications - 79
Citations - 1131
Jens Aberle is an academic researcher from University of Hamburg. The author has contributed to research in topics: Weight loss & Medicine. The author has an hindex of 14, co-authored 65 publications receiving 870 citations.
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Journal ArticleDOI
Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans
Andrew C. Edmondson,Robert J. Brown,Sekar Kathiresan,L. Adrienne Cupples,Serkalem Demissie,Alisa K. Manning,Majken K. Jensen,Eric B. Rimm,Jian Wang,Amrith Rodrigues,Vaneeta Bamba,Sumeet A. Khetarpal,Megan L. Wolfe,Stephanie DerOhannessian,Mingyao Li,Muredach P. Reilly,Jens Aberle,David M. Evans,Robert A. Hegele,Daniel J. Rader +19 more
TL;DR: The results establish that loss-of-function mutations in LIPG lead to increased HDL-C levels and support the idea that inhibition of endothelial lipase may be an effective mechanism to raise HDL- C.
Posted ContentDOI
The majority of male patients with COVID-19 present low testosterone levels on admission to Intensive Care in Hamburg, Germany: a retrospective cohort study.
Maria Schroeder,berfin schaumburg,Zacharias Mueller,Ann Parplys,Dominik Jarczak,Axel Nierhaus,Andreas Kloetgen,Bettina Schneider,Manuela Peschka,Fabian Stoll,Tian Bai,Henning Jacobsen,Martin Zickler,Stephanie Stanelle-Bertram,Geraldine de Heer,Thomas Renné,Andreas Meinhardt,Joerg Heeren,Jens Aberle,Alice C. McHardy,Hartmut Schlueter,Jens Hiller,Sven Peine,Lothar Kreienbrock,Karin Klingel,Stefan Kluge,Guelsah Gabriel +26 more
TL;DR: It is shown that critically ill male COVID-19 patients suffer from severe testosterone and dihydrotestosterone deficiencies, which are required to mount antiviral immune responses to combat infection in males.
Journal ArticleDOI
A polymorphism in the apolipoprotein A5 gene is associated with weight loss after short-term diet
TL;DR: In a group of 606 hyperlipaemic and overweight men, this work investigated how a short‐term fat restriction affects lipid traits and body mass index (BMI) in wildtype and carriers of the −1131T > C polymorphism and found the reduction of BMI was significantly higher in C allele carriers.
Journal ArticleDOI
Genetic variation may influence obesity only under conditions of diet: Analysis of three candidate genes
Jens Aberle,Jörg Flitsch,Nicola Alessia Beck,Oliver Mann,Philipp Busch,Philipp Peitsmeier,F. U. Beil +6 more
TL;DR: In conclusion, genetic polymorphisms associated with obesity may become relevant only under the condition of a low calory diet and the presence of a certain genotype may then be beneficial for obesity treatment.
Journal ArticleDOI
Association of the T+294C polymorphism in PPAR δ with low HDL cholesterol and coronary heart disease risk in women
TL;DR: The data show for the first time that the PPARδ +T294C polymorphism is associated with lipid levels and coronary heart disease in women, however, the molecular mechanism of action remains to be elucidated.