Showing papers by "Jerome N. Sanes published in 1987"
TL;DR: Comparisons of cortical motor representation of normal adult rats with adult rats that had one forelimb removed on the day of birth demonstrate that representation patterns in motor cortex can be altered by peripheral nerve injury during development.
Abstract: We investigated the effect of neonatal nerve lesions on cerebral motor cortex organization by comparing the cortical motor representation of normal adult rats with adult rats that had one forelimb removed on the day of birth. Mapping of cerebral neocortex with electrical stimulation revealed an altered relationship between the motor cortex and the remaining muscles. Whereas distal forelimb movements are normally elicited at the lowest threshold in the motor cortex forelimb area, the same stimuli activated shoulder and trunk muscles in experimental animals. In addition, an expanded cortical representation of intact body parts was present and there was an absence of a distinct portion of motor cortex. These data demonstrate that representation patterns in motor cortex can be altered by peripheral nerve injury during development.
62 citations