Showing papers by "Jerónimo Saiz-Ruiz published in 1997"
TL;DR: A Spanish sample consisting of 68 Caucasian pathological gambling patients and 68 unaffected controls screened by the molecular analysis of a functional DNA polymorphism in the locus for the D4 dopamine receptor gene provides new evidence of the implication of the dopaminergic reward pathways through the involvement of DRD4 in the aetiology of this impulsive disorder.
Abstract: A Spanish sample consisting of 68 Caucasian pathological gambling patients (47 males and 21 females) and 68 unaffected controls were screened by the molecular analysis of a functional DNA polymorphism in the locus for the D4 dopamine receptor gene. Our results are consistent with the existence of a significant association between genetic variants at a DRD4 gene polymorphism and pathological gambling (chi 2 = 11.82; P = 0.037). This association seems to be sex-influenced, since there was no significant association when only males were considered (chi 2 = 9.45; P = 0.09), but there was a more significant association if we only considered female subjects (chi 2 = 8.73; P = 0.033). Individuals with the longest allele (D7) were the most frequent in affected females (chi 2 = 4.50; P = 0.033). This work provides a new evidence of the implication of the dopaminergic reward pathways, now through the involvement of DRD4, in the aetiology of this impulsive disorder.
148 citations