J
Jessica K. Alexander
Researcher at Ohio State University
Publications - 14
Citations - 2841
Jessica K. Alexander is an academic researcher from Ohio State University. The author has contributed to research in topics: Neuropathic pain & Cognitive flexibility. The author has an hindex of 10, co-authored 14 publications receiving 2504 citations.
Papers
More filters
Journal ArticleDOI
Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord.
Kristina A. Kigerl,John C. Gensel,Daniel P. Ankeny,Jessica K. Alexander,Dustin J. Donnelly,Phillip G. Popovich +5 more
TL;DR: Together, these data suggest that polarizing the differentiation of resident microglia and infiltrating blood monocytes toward an M2 or “alternatively” activated macrophage phenotype could promote CNS repair while limiting secondary inflammatory-mediated injury.
Journal ArticleDOI
Beta-adrenergic Modulation of Cognitive Flexibility during Stress
TL;DR: Results indicate that stress impaired performance on cognitive flexibility tasks, but not control tasks; compared to placebo, cognitive flexibility improved during stress with propranolol, which may provide support for the hypothesis that stress-related impairments in cognitive flexibility are related to the noradrenergic system.
Book ChapterDOI
Neuroinflammation in spinal cord injury: therapeutic targets for neuroprotection and regeneration.
TL;DR: The potential of the neuroinflammatory response to cause outcomes such as pain, regeneration, and functional recovery is reviewed and the importance of microenvironmental cues generated by the cells therein is reviewed.
Journal ArticleDOI
2006 Curt P. Richter award winner: Social influences on stress responses and health
TL;DR: In this paper, positive and negative social interactions can modulate the hypothalamic-pituitary-adrenal (HPA) axis and influence recovery from injuries and illnesses, such as wounds, stroke, and cardiac arrest.
Journal ArticleDOI
Stress exacerbates neuropathic pain via glucocorticoid and NMDA receptor activation.
Jessica K. Alexander,A. Courtney DeVries,Kristina A. Kigerl,Jason M. Dahlman,Phillip G. Popovich +4 more
TL;DR: The data suggest that the hormonal responses elicited by stress exacerbate neuropathic pain through enhanced central sensitization, and drugs that inhibit glucocorticoids and/or NMDAR signaling could ameliorate pain syndromes caused by stress.