J
Jesús Santa-Olalla
Researcher at National Autonomous University of Mexico
Publications - 8
Citations - 316
Jesús Santa-Olalla is an academic researcher from National Autonomous University of Mexico. The author has contributed to research in topics: Neurosphere & Precursor cell. The author has an hindex of 6, co-authored 8 publications receiving 312 citations.
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Epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha), and basic fibroblast growth factor (bFGF) differentially influence neural precursor cells of mouse embryonic mesencephalon.
TL;DR: Data indicate the existence of neural precursor cells in the embryonic mesencephalon that respond differentially to growth factors, and suggest that most cells with the capacity to form colonies responded to EGF, TGF‐α, or bFGF.
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Basic fibroblast growth factor promotes epidermal growth factor responsiveness and survival of mesencephalic neural precursor cells.
TL;DR: It is shown that 13.5 dpc dorsal mesencephalic cells required bFGF only for 1 h to form colonies in response to EGF alone, indicating that these two growth factors act in sequence rather than simultaneously.
Journal ArticleDOI
The in vivo positional identity gene expression code is not preserved in neural stem cells grown in culture.
Jesús Santa-Olalla,José-Manuel Baizabal,Mariana Fregoso,María Del Carmen Cárdenas,Luis Covarrubias +4 more
TL;DR: It is proposed that signals surrounding NSCs determine their positional identity gene expression code, which may be relevant to establish their definitive fate.
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Neural stem cells in development and regenerative medicine
TL;DR: It is proposed that both abnormal cell death activation and decreased natural neuronal regeneration can contribute to the neuronal loss associated with aging, and perhaps even with that occurring in some neurodegenerative diseases.
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Growth factor deprivation induces an alternative non-apoptotic death mechanism that is inhibited by Bcl2 in cells derived from neural precursor cells.
Maria del Carmen Cardenas-Aguayo,Jesús Santa-Olalla,José-Manuel Baizabal,Luis-Miguel Salgado,Luis Covarrubias +4 more
TL;DR: It is proposed that anti-apoptotic Bcl2 family members are key molecules controlling death activation independently of the cell degeneration mechanism used.