J
Ji-Xiang He
Researcher at Protein Sciences
Publications - 2
Citations - 30
Ji-Xiang He is an academic researcher from Protein Sciences. The author has contributed to research in topics: Chemical biology & Chemistry. The author has an hindex of 1, co-authored 2 publications receiving 10 citations.
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A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes.
Ling Fu,Ling Fu,Zongmin Li,Zongmin Li,Keke Liu,Caiping Tian,Caiping Tian,Ji-Xiang He,Jingyang He,Fuchu He,Fuchu He,Ping Xu,Ping Xu,Jing Yang +13 more
TL;DR: A new chemoproteomic platform, termed ‘QTRP’ (quantitative thiol reactivity profiling), that relies on the ability of a commercially available thiol-reactive probe IPM (2-iodo-N-(prop-2-yn-1-yl)acetamide) to covalently label, enrich and quantify the reactive cysteinome in cells and tissues is developed.
Journal ArticleDOI
A Paal–Knorr agent for chemoproteomic profiling of targets of isoketals in cells
TL;DR: ONAyne permitted global, in situ, and site-specific profiling of targeted lysine residues of two specific isomers of isoketals, levuglandin (LG) D2 and E2, and functional analyses reveal that LG-derived adduction drives inhibition of malate dehydrogenase MDH2 and exhibits a crosstalk with two epigenetic marks on histone H2B in macrophages.