J
Jian Ni
Researcher at Beijing University of Chinese Medicine
Publications - 86
Citations - 2815
Jian Ni is an academic researcher from Beijing University of Chinese Medicine. The author has contributed to research in topics: Apoptosis & Emodin. The author has an hindex of 20, co-authored 85 publications receiving 1639 citations. Previous affiliations of Jian Ni include Peking University.
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Underlying mechanisms of apoptosis in HepG2 cells induced by polyphyllin I through Fas death and mitochondrial pathways.
Yawen Zeng,Zhiqin Zhang,Wenping Wang,Longtai You,Xiaoxv Dong,Xingbin Yin,Changhai Qu,Jian Ni +7 more
TL;DR: The results suggested that Polyphylin I inhibited cell proliferation and growth by triggering G2/M cell cycle arrest, and induced apoptosis through intracellular and extracellular apoptosis pathways to cause cell death by generating reactive oxygen species.
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Altered plasma and brain disposition of isopropylidene shikimic acid liposome in rats and the brain protection in cerebral ischemia-reperfusion.
Changhai Qu,Jian Ni,Pei Yang,Hui Zhang,Longfei Lin,Jiang Li,Jingchen Tian,Jing Fu,Xingbin Yin,Hui Kong +9 more
TL;DR: The results revealed that the liposomal DDS was potential as a novel strategy for the treatment of cerebral I/R injury and further targeted modification, such as PEG-modified liposomes, which possess a long circulating property in the bloodstream, would further improve the targeting delivery to the brain and lead to more significant efficacy.
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Simultaneous Determination of Typhaneoside and Isorhamnetin-3-O-Neohesperidoside in Rats After Oral Administration of Pollen Typhae Extract by UPLC–MS/MS
TL;DR: A selective and rapid ultra-performance liquid chromatography method with tandem mass spectrometric (UPLC-MS/MS) detection for simultaneous determination of typhaneoside and isorhamnetin-3-O-neohesperidoside in rat plasma was developed and validated, which was applied to the pharmacokinetic study of Pollen Typhae extract.
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In-vitro and in-vivo comparison of T-OA microemulsions and solid dispersions based on EPDC.
Peng Hou,Sali Cao,Jian Ni,Tao Zhang,Zhengjun Cai,Juanjuan Liu,Ye Wang,Penglong Wang,Haimin Lei,Yong Liu +9 more
TL;DR: Results indicated that, compare to improve the solubility, it is more important to maintain and prolong the T-OA dissolved status, for improvement of the in-vivo absorption.
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Biological effects based quality control of a traditional Chinese medicine
Jianxin Chen,Xueling Ma,Huihui Zhao,Ying Yang,Jing Han,Shuzhen Guo,Bing Liu,Jian Ni,Wei Wang +8 more
TL;DR: A quality control method based on lipid-lowering and anti-oxidation effect of Jiang-Zhi-Ning (JZN) is established and evidence for quality standard evaluation system of Chinese herbal compound is provided.