J
Jianhua Rao
Researcher at Nanjing Medical University
Publications - 55
Citations - 1216
Jianhua Rao is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Reperfusion injury & Medicine. The author has an hindex of 16, co-authored 46 publications receiving 912 citations. Previous affiliations of Jianhua Rao include University of California, Los Angeles.
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Journal ArticleDOI
ATF6 Mediates a Pro‐Inflammatory Synergy Between ER Stress and TLR Activation in the Pathogenesis of Liver Ischemia‐Reperfusion Injury
Jianhua Rao,S. Yue,Yuanfang Fu,Jianjun Zhu,Xuehao Wang,Ronald W. Busuttil,Jerzy W. Kupiec-Weglinski,Ling Lu,Yuan Zhai +8 more
TL;DR: Ischemia primes liver innate immune cells by ATF6‐mediated ER stress response, and the IR‐induced metabolic stress and TLR activation function in synergy to activate tissue inflammatory immune response.
Journal ArticleDOI
ATF3-mediated NRF2/HO-1 signaling regulates TLR4 innate immune responses in mouse liver ischemia/reperfusion injury.
Jianhua Rao,X Qian,Gang Li,Xiongxiong Pan,Chuang-Yong Zhang,Feng Zhang,Yuan Zhai,Yuan Zhai,Xuehao Wang,Ling Lu +9 more
TL;DR: The results first demonstrate ATF3‐mediated NRF2/HO‐1 signaling in the regulation of TLR4‐driven inflammatory responses in IR‐stressed livers, and provide a rationale for a novel therapeutic strategy for managing IR‐induced liver injury.
Journal ArticleDOI
miR-665 promotes hepatocellular carcinoma cell migration, invasion, and proliferation by decreasing Hippo signaling through targeting PTPRB
TL;DR: The results suggested that miR-665 was a negative regulator of the PTPRB and could promote tumor proliferation and metastasis in HCC through decreasing Hippo signaling pathway activity, which can be a potential target for HCC treatment.
Journal ArticleDOI
Myeloid PTEN Deficiency Protects Livers from Ischemia Reperfusion Injury by Facilitating M2 Macrophage Differentiation
Shi Yue,Jianhua Rao,Jianhua Rao,Jianjun Zhu,Jianjun Zhu,Ronald W. Busuttil,Jerzy W. Kupiec-Weglinski,Ling Lu,Xuehao Wang,Yuan Zhai +9 more
TL;DR: Myeloid PTEN deficiency protects livers from IRI by facilitating M2 macrophage differentiation, and activation of Kupffer cells by gadolinium chloride enhanced proinflammatory immune activation and increased IRI in livers of myeloids PTEN KO mice.
Journal ArticleDOI
N-acetylcysteine attenuates reactive-oxygen-species-mediated endoplasmic reticulum stress during liver ischemia-reperfusion injury
TL;DR: This study provides new evidence for the protective effects of NAC treatment on hepatocytes during IRI through inhibition of ROS-mediated ER stress, NAC may be critical to inhibit the ER-stress-related apoptosis pathway.