Showing papers by "Jiayou Chu published in 2014"

[Association of three polymorphisms in the 3' untranslated region of the HLA-G gene with systemic lupus erythematosus in a population from Yunnan].

Abstract: Objective To assess the association of three polymorphisms （14-bplNS/DEL, ＋3035C/ T and ＋ 3142C/G） in the 3＇ untranslated region （3＇ UTR） of HLA-G gene and systemic lupus erythematosus （SLE） in Yunnan. Methods A case-control study has been carried out on 206 SLE patients and 212 healthy controls. Genotypes of 14-bpINS/DEL （rs1704）, ＋3035C/T （rs17179108） and ＋3142C/ G （rs1063320） loci of 3＇UTR of the HLA-G gene were determined with DNA sequencing. Results Allelic and genotypic frequencies of 14-bpINS/DEL and ＋ 3142C/G did not differ significantly between the two groups （P〉0.05）. The frequencies of ＋3035T allele was significantly higher in the SLE group compared with the control group （P〈0. 01, OR ： 1. 604, 95% CI： 1. 186-2. 169）. With a dominant inheritance model, the odd ratio of dominant genotype （CT＋TT） was 2. 004 （95%CI： 1. 345-2. 987, P=O. 0006） in the SLE group. Conclusion The 14-bpINS/DEL and ＋ 3142C/G polymorphisms in the 3＇ UTR of the HLA-G gene are not associated with susceptibility to SLE in Yunnan, whilst the T allele of ＋3035C/T may be a risk factor for SLE. Key words: HLA-G gene; Systemic lupus erythematosus; Association analysis; Polymorphism