An electronic circuit device includes a case and a cover between which a space is defined, electronic circuit parts arranged in the space, and a sealant to seal the electronic circuit parts The case has a bottom face, a side wall, and an opening face opposing to the bottom face The cover is located inside of the side wall so as to close the opening face of the case The cover has a filling port through which the sealant is filled The cover has a top face located approximately equal to an end face of the side wall, or adjacent to the bottom face relative to the end face of the side wall

Electronic circuit device

The invention relates to a group of compounds of formula (I), which contain a chromene nucleus and can inhibit lymphocyte proliferation owing to the TCR-Nck interaction, said invention also relating to the use of these compounds for the treatment of diseases or conditions in which the aforementioned interaction triggers a complication, such as transplant rejection reactions, immune or autoimmune diseases, inflammatory diseases or proliferative diseases.

Chromene derivatives as inhibitors of tcr-nck interaction

본 발명은 심장 혈관계 장애를 치료, 특히 부정맥을 치료하거나, 돌연 심장사를 예방하거나 저하된 심장 수축성에 영향을 주기에 유용한 약제학적 활성 화합물인 화학식 1의 3-아미도크로마닐설포닐(티오)우레아, 이의 제조방법, 이의 용도 및 이를 포함하는 약제학적 제제에 관한 것이다. 화학식 1

3-아미도크로마닐설포닐우레아,이의제조방법및이를포함하는약제학적조성물

PROBLEM TO BE SOLVED: To provide a method for effectively, safely, industrially and advantageously producing 2,5-dihidroxy benzaldehyde compound without needing exclusive facilities.SOLUTION: A method for producing 2,5-dihidroxy benzaldehyde compound includes a step (I) of reacting a compound (2) with paraformaldehyde, a step (II) of bringing the obtained reaction liquid into contact with an acid and a base to obtain a solution of a compound (3), a step (III) of deprotecting a protected group Rwithout isolating the compound (3) from the obtained solution.

Method for producing 2,5-dihydroxy benzaldehyde compound

A novel N-hydroxyurea derivative represented by formula (I) and having antiallergic and anti-inflammatory effects, i.e., N-hydroxy-N-[6-(3-pyridylmethyl)-2H-1-benzopyran-3-ylmethyl]urea; and medicines containing the above derivative or a pharmacologically acceptable salt thereof, or a hydrate or solvate thereof as the active ingredient, particularly antiallergic or anti-inflammatory agent, especially antiasthmatic.

N-hydroxyurea derivative and medicine containing the same

The invention relates to the compounds of the formula wherein each R independently represents hydrogen, lower alkyl, halogen, trifluoromethyl, lower alkoxy, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic aryloxy, carbocyclic or heterocyclic aryl-lower alkyloxy, carbocyclic or heterocyclic aryl-lower alkyl, C3-C7-cycloalkyl-lower alkyloxy, or C3-C7-cycloalkyloxy; R1 represents hydrogen, lower alkyl or carbocyclic aryl; R2 represents hydrogen or lower alkyl; Y represents oxygen (O), sulfur (S), sulfinyl or sulfonyl; n represents 1, 2 or 3; A represents a direct bond or lower alkylene; Z represents wherein R3 represents hydrogen or acyl; R4 represents lower alkyl, C3-C7-cycloalkyl, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic aryl-lower alkyl, or C3-C7-cycloalkyl-lower alkyl; or Z represents wherein X represents oxygen or sulfur, R3 represents hydrogen or acyl; R5 represents lower alkyl, lower alkoxycarbonyl-lower alkyl, C3-C7-cycloalkyl, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic aryl-lower alkyl, C3-C7-cycloalkyl-lower alkyl, amino, mono- or di-lower alkylamino, lower alkenylamino, lower alkynylamino, carbocyclic or heterocyclic aryl-lower alkylamino, carbocyclic or heterocyclic arylamino, C3-C7-cycloalkylamino, C3-C7-cycloalkyl-lower alkylamino, lower alkoxycarbonyl-lower alkylamino, or lower alkoxy; R6 and R7 independently represent hydrogen or lower alkyl; and pharmaceutically acceptable salts thereof; which are useful as 5-lipoxygenase inhibitors.

Jieimuzu Roorensu Sutanton

Papers

New benzopyran and benzothio- pyran derivatives