J
Jim L. Rupert
Researcher at Case Western Reserve University
Publications - 3
Citations - 1318
Jim L. Rupert is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: XIST & X chromosome. The author has an hindex of 3, co-authored 3 publications receiving 1244 citations. Previous affiliations of Jim L. Rupert include Stanford University & University of British Columbia.
Papers
More filters
Journal ArticleDOI
The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus.
Carolyn J. Brown,Brian Hendrich,Jim L. Rupert,Ronald G. Lafreniere,Yigong P. Xing,Jeanne B. Lawrence,Huntington F. Willard +6 more
TL;DR: Human XIST cDNAs containing at least eight exons and totaling 17 kb have been isolated and sequenced within the region on the X chromosome known to contain the X inactivation center, suggesting that XIST may function as a structural RNA within the nucleus.
Journal ArticleDOI
The DXS423E gene in Xp11.21 escapes X chromosome inactivation
Carolyn J. Brown,Andrew P. Miller,Andrew P. Miller,Laura Carrel,Laura Carrel,Jim L. Rupert,Kay E. Davies,Huntington F. Willard +7 more
TL;DR: The DXS423E and XE169 genes define a new region in the proximal short arm of the X chromosome that is not subject to X chromosome inactivation, supporting a regional basis for escape from inactivation.
Journal ArticleDOI
Direct Detection of Non-Random X Chromosome Inactivation by Use of a Transcribed Polymorphism in the XIST Gene
TL;DR: Identification of a single-base polymorphism in an expressed region of the human XIST gene has permitted the development of a direct PCR-based assay for randomness of X inactivation, and non-random X chromosome inactivation has been demonstrated in chromosomally abnormal cell lines and in lymphocytes from heterozygous, normal females.