Jinbao Wei

TL;DR: More than half of the studies included showed it was positive to treat anxiety symptoms by regulation of intestinal microbiota, and it should be highlighted that the non-probiotic interventions were more effective than the probiotic interventions.

TL;DR: It is found that juvenile rats subjected to 4 h daily NMS during postnatal days 1 to 20 exhibited autistic-like behavioral deficits without impairments in learning and memory functions and the potential for NMS-driven epigenetic tuning of OXTR expression is suggested.

TL;DR: In this article, the authors investigated the regulation of pain hypersensitivity induced by the spinal synaptic transmission mechanisms underlying interleukin (IL)-10 and glucagon-like peptide 1 receptor (GLP-1R) agonist exenatide-induced pain anti-hypersensitivity in neuropathic rats through spinal nerve ligations.

TL;DR: It is suggested that BAA produces visceral antinociception by stimulating spinal microglial release of dynorphin A, which activates presynaptic κ-opioid receptors in afferent neurons and inhibits spinal synaptic plasticity, highlighting a novel interaction mode between microglia and neurons.

TL;DR: The cytotoxicity test indicated that 12g merits further optimization and development as a new podophyllotoxin-derived lead compound, and the docking studies showed possible interactions between human DNA topoisomerase IIα and 12g.