Yong-Xiang Wang

TL;DR: Results show that: 1) selective N-type VSCC blockers are potent and efficacious antinociceptive agents when they are administered by the spinal route; 2) selective VSC blockers are effective in rat models of acute, persistent and neuropathic pain; and 3) N- type VSCCs play a significant role in the spinal processing of noxious somatosensory input.

TL;DR: Although ziconotide in combination with morphine produced an apparent synergistic analgesic effects during the initial phase of continuous infusion, it did not prevent morphine tolerance to analgesia and does not prevent or reverse morphine tolerance.

TL;DR: It is shown that intrathecal ziconotide is antinociceptive in a rat incisional model of post‐operative pain and is more potent, longer acting, and more specific in its actions than intrathecally morphine.

TL;DR: The results illustrate a novel spinal dorsal horn microglial GLP-1R/β-endorphin inhibitory pathway in a variety of pain hypersensitivity states that potently alleviated formalin, peripheral nerve injury, bone cancer, and diabetes-induced hypers sensitivity states.

TL;DR: The groups of compounds discussed are benzylisoquinolines, tetrahydropyrazine, rhynchophylline and hirsutine, ginkgolides and other PAF inhibitors, coumarins, and ginsenosides, plus a miscellaneous group; approximately 30 substances in all.