J
Jing He
Researcher at University of Pittsburgh
Publications - 32
Citations - 6596
Jing He is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Islet & Transplantation. The author has an hindex of 24, co-authored 32 publications receiving 6137 citations. Previous affiliations of Jing He include Boston Children's Hospital.
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Journal ArticleDOI
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
TL;DR: It is concluded that there is an impaired bioenergetic capacity of skeletal muscle mitochondria in type 2 diabetes, with some impairment also present in obesity.
Journal ArticleDOI
Skeletal Muscle Lipid Content and Insulin Resistance: Evidence for a Paradox in Endurance-Trained Athletes
TL;DR: Skeletal muscle of trained endurance athletes is markedly insulin sensitive and has a high oxidative capacity, despite having an elevated lipid content, according to quantitative image analysis of Oil Red O staining.
Journal ArticleDOI
Deficiency of Subsarcolemmal Mitochondria in Obesity and Type 2 Diabetes
Vladimir B. Ritov,Elizabeth V. Menshikova,Jing He,Robert E. Ferrell,Bret H. Goodpaster,David E. Kelley +5 more
TL;DR: Although mtDNA was lower in type 2 diabetic and obese subjects, the decrement in electron transport chain activity was proportionately greater, indicating functional impairment, which may contribute to the pathogenesis of muscle insulin resistance in type 1 diabetes.
Journal ArticleDOI
Skeletal Muscle Lipid Content and Oxidative Enzyme Activity in Relation to Muscle Fiber Type in Type 2 Diabetes and Obesity
TL;DR: Based on single-fiber analysis, skeletal muscle in obese and type 2 diabetic subjects mani-fests disturbances of oxidative enzyme activity and increased lipid content that are independent of the effect of fiber type are found.
Journal ArticleDOI
Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets.
D. J. van der Windt,Rita Bottino,Anna Casu,N Campanile,Cynthia Smetanka,Jing He,Noriko Murase,Hidetaka Hara,Suyapa Ball,Bruce E. Loveland,D. Ayares,Fadi G. Lakkis,David K. C. Cooper,Massimo Trucco +13 more
TL;DR: Inhibition of complement activation by the expression of hCD46 on the pig islets did not substantially reduce the initial loss of islet mass, but was effective in limiting antibody‐mediated rejection, which resulted in a reduced need for immunosuppression to maintain normoglycemia long‐term.