A
Anna Casu
Researcher at ISMETT
Publications - 41
Citations - 1243
Anna Casu is an academic researcher from ISMETT. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 16, co-authored 26 publications receiving 1129 citations. Previous affiliations of Anna Casu include University of Pittsburgh & Boston Children's Hospital.
Papers
More filters
Journal ArticleDOI
Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets.
D. J. van der Windt,Rita Bottino,Anna Casu,N Campanile,Cynthia Smetanka,Jing He,Noriko Murase,Hidetaka Hara,Suyapa Ball,Bruce E. Loveland,D. Ayares,Fadi G. Lakkis,David K. C. Cooper,Massimo Trucco +13 more
TL;DR: Inhibition of complement activation by the expression of hCD46 on the pig islets did not substantially reduce the initial loss of islet mass, but was effective in limiting antibody‐mediated rejection, which resulted in a reduced need for immunosuppression to maintain normoglycemia long‐term.
Journal ArticleDOI
Rapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies.
Dirk J. van der Windt,Dirk J. van der Windt,Rita Bottino,Anna Casu,Nathalie Campanile,Nathalie Campanile,David K. C. Cooper +6 more
TL;DR: The future of clinical islet transplants will, at least in part, depend on the success of efforts made to reduce rapid graft loss, and thus allow islet transplantation to become a more efficient therapy by the use of single donors.
Journal ArticleDOI
Clinical Islet Xenotransplantation How Close Are We
Dirk J. van der Windt,Rita Bottino,Goutham Kumar,Martin Wijkstrom,Hidetaka Hara,Mohamed Ezzelarab,Burcin Ekser,Carol Phelps,Noriko Murase,Anna Casu,David Ayares,Fadi G. Lakkis,Massimo Trucco,David K. C. Cooper +13 more
TL;DR: Recent progress in preclinical models of pig islet xenotransplantation is reviewed and the remaining challenges that need to be addressed are discussed before the application of this form of therapy can be established in patients with T1D.
Journal ArticleDOI
Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice
Anna Casu,Rita Bottino,A.N. Balamurugan,A.N. Balamurugan,Hidetaka Hara,D. J. van der Windt,Nathalie Campanile,Nathalie Campanile,Cynthia Smetanka,David K. C. Cooper,Massimo Trucco +10 more
TL;DR: The transplantation data indicated that the degree of graft function necessary to normalise blood glucose in the recipient was determined by the recipient levels rather than by the donor levels, which need to be considered when assessing graft function in xenotransplantation models.
Journal ArticleDOI
Endoscopic gastric submucosal transplantation of islets (ENDO-STI): technique and initial results in diabetic pigs.
Gabriel J. Echeverri,Kevin McGrath,Rita Bottino,Hidetaka Hara,Eefje M. Dons,Eefje M. Dons,D. J. van der Windt,D. J. van der Windt,Burcin Ekser,Burcin Ekser,Anna Casu,Stuart L. Houser,Mohamed Ezzelarab,Robert Wagner,Massimo Trucco,Fadi G. Lakkis,David K. C. Cooper +16 more
TL;DR: Endoscopic gastric submucosal transplantation of islets (ENDO‐STI) offers a minimally invasive and quick approach to islet transplantation, avoids IBMIR and warrants further exploration.