J
Jing Xu
Researcher at Peking Union Medical College
Publications - 93
Citations - 2289
Jing Xu is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 20, co-authored 74 publications receiving 1592 citations. Previous affiliations of Jing Xu include Shanxi Medical University & Huazhong University of Science and Technology.
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Journal ArticleDOI
Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated double-stranded DNA cleavage
Jian-Ping Zhang,Xiao-Lan Li,Guo-Hua Li,Wanqiu Chen,Cameron Arakaki,Gary D. Botimer,David J. Baylink,Lu Zhang,Wei Wen,Ya-Wen Fu,Jing Xu,Noah Chun,Weiping Yuan,Tao Cheng,Xiao-Bing Zhang +14 more
TL;DR: It is shown that a double cut HDR donor, which is flanked by single guide RNA (sgRNA)-PAM sequences and is released after CRISPR/Cas9 cleavage, increases HDR efficiency by twofold to fivefold relative to circular plasmid donors.
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CRISPR-mediated Genome Editing Restores Dystrophin Expression and Function in mdx Mice
TL;DR: It is demonstrated that CRIPSR-mediated genome editing efficiently excised a 23-kb genomic region on the X-chromosome covering the mutant exon 23 in a mouse model of DMD, and restored dystrophin expression and the dyStrophin-glycoprotein complex at the sarcolemma of skeletal muscles in live mdx mice.
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SIRT1 Suppresses Activator Protein-1 Transcriptional Activity and Cyclooxygenase-2 Expression in Macrophages
Ran Zhang,Hou-Zao Chen,Jinjing Liu,Yuyan Jia,Zhu-Qin Zhang,Ruifeng Yang,Yuan Zhang,Jing Xu,Yu-Sheng Wei,De-Pei Liu,Chih-Chuan Liang +10 more
TL;DR: The results indicate that SIRT1 may be a mediator of CR-induced macrophage regulation, and its deacetylase activity contributes to the inhibition of AP-1 transcriptional activity and COX-2 expression leading to amelioration of macrophages function.
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Spatially resolved metabolomics to discover tumor-associated metabolic alterations.
Chenglong Sun,Tiegang Li,Xiaowei Song,Luojiao Huang,Qingce Zang,Jing Xu,Nan Bi,Guanggen Jiao,Yanzeng Hao,Yanhua Chen,Ruiping Zhang,Zhigang Luo,Xin Li,Luhua Wang,Zhonghua Wang,Yongmei Song,Jiuming He,Zeper Abliz,Zeper Abliz +18 more
TL;DR: The spatially resolved metabolomics reveal what occurs in cancer at the molecular level, from metabolites to enzymes, and thus provide insights into the understanding of cancer metabolic reprogramming.
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Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice
TL;DR: It is demonstrated that SIRT1 overexpression in VSMCs reduces SBP and inhibits AngII-induced vascular remodeling in mice, which contributes, at least in part, to the antihypertensive effect of SIRT 1.